Oats

Overview

Oats provide beta-glucan fiber (prebiotic), tryptophan, B vitamins, and complex carbohydrates that support gut health, serotonin synthesis, and stable glucose release. Beta-glucans are prebiotic fibers that support gut microbiome health. Oats are listed as a source for tryptophan, which serves as a serotonin precursor and can be converted to NAD+ via kynurenine pathway. Clinical trials have shown a doubling of plasma levels after dietary increases in oat bran due to its rich phosphatidylethanolamine (PE) content, which supports endocannabinoid system tone.

Recipes

1 recipe containing this food

Chocolate Quinoa Crisp Clusters

A delicious cereal-to-snack hybrid with satisfying crunch, steady energy, and a low glycemic profile. Perfect for breakfast or anytime snacking.

Substances

16 substances in this food

Histidine

Essential AA; precursor to histamine; roles in enzyme active sites

Iron

Oxygen transport; dopamine synthesis (tyrosine hydroxylase cofactor)

Isoleucine

Essential BCAA; energy metabolism; complements leucine/valine

Leucine

Essential BCAA; mTOR signaling; protein synthesis; cognitive load support

Lysine

Essential AA; limiting in many cereals; complements legumes

Magnesium

Enzymatic cofactor (>300 reactions); neurotransmitters; mitochondria; redox balance

Manganese

Cofactor for MnSOD (SOD2); mitochondrial antioxidant defense

Methionine

Essential AA; precursor to SAMe via methylation cycle

Phenylalanine

Essential AA; precursor to tyrosine → catecholamines

Phosphatidylethanolamine (PE)

Brain phospholipid; precursor to PC and NAPE → NAEs (PEA/OEA/AEA)

Threonine

Essential AA; structural proteins; mucin production

Tryptophan

Serotonin/melatonin precursor; NAD+ pathway substrate; LAT1 transport dynamics

Valine

Essential BCAA; supports protein balance and neurotransmitter transport competition

Vitamin B1 (Thiamine)

Mitochondrial glucose metabolism; ATP synthesis; rapid turnover in CNS

Vitamin B6 (Pyridoxine → PLP)

PLP cofactor for neurotransmitter synthesis; relies on brain PDXK activation

Zinc

Cofactor in neurotransmission and antioxidant enzymes; dopamine modulation

Preparation Notes

• Soak overnight to reduce phytates and improve mineral bioavailability
• Pair with tryptophan-rich proteins for serotonin synthesis; pair tryptophan-rich proteins with moderate carbs to increase Trp:LNAA ratio
• Best consumed in evening for calming effect; timing midday or evening for calming effect
• Part of grain-legume complementarity strategy; grains (typically lysine-limited) and legumes (methionine/cysteine-limited) complete each other's profiles when paired
• Tryptophan + complex carbohydrates aid serotonin conversion to melatonin; examples include pumpkin seeds + oats

Biological Target Matrix

Biological Target	Substance	Therapeutic Areas	Mechanism of Action
Endocannabinoid System (ECS)	Phosphatidylethanolamine (PE)	ADHD, Anxiety & GAD, Depression & MDD	Key brain phospholipid that can convert to PC or N-acyl phosphatidylethanolamines (NAPEs); NAPEs are precursors to N-acyl ethanolamines (NAEs) like palmitoylethanolamide (PEA), oleoylethanolamide (OEA), and anandamide (AEA), bioactive lipids which act as neuromodulators with anti-inflammatory, neuroprotective, and mood-regulating effects
Hormonal Response	Magnesium	ADHD, Anxiety & GAD	Supports calcium modulation along with vitamin D, taurine, phospholipids, and flavonoids; supports insulin sensitivity, sympathetic arousal, and mitochondrial excitability
Inflammation	Zinc	ADHD, Anxiety & GAD, Depression & MDD, Alzheimer's Disease, Bipolar Disorder	Supports immune signaling; gut barrier integrity disrupted by nutrient deficiencies including zinc
Insulin Response	Magnesium	ADHD, Anxiety & GAD, Depression & MDD	Supports insulin sensitivity and glucose metabolism; magnesium deficiency is associated with insulin resistance; supports enzymes involved in glucose metabolism
Insulin Response	Vitamin B1 (Thiamine)	ADHD, Anxiety & GAD, Depression & MDD	Supports glucose metabolism and insulin sensitivity through mitochondrial function
Methylation	Methionine	ADHD, Anxiety & GAD, Depression & MDD, Alzheimer's Disease	Essential amino acid that forms S-adenosylmethionine (SAMe), the universal methyl donor for neurotransmitter synthesis and membrane phospholipid methylation
Methylation	Vitamin B6 (Pyridoxine → PLP)	ADHD, Anxiety & GAD, Depression & MDD, Alzheimer's Disease	Essential cofactor in remethylation of homocysteine to methionine, which is converted to S-adenosylmethionine (SAMe); works with B2, folate, and B12
Methylation	Zinc	ADHD, Anxiety & GAD, Depression & MDD, Alzheimer's Disease	Deficiencies in vitamins and minerals essential for methylation, such as folate, vitamin B12, and zinc, are correlated to ADHD symptoms; supplementing these micronutrients has shown potential in supporting methylation and reducing symptom severity
Mitochondrial Support	Iron	ADHD, Anxiety & GAD, Depression & MDD, Alzheimer's Disease, Bipolar Disorder	Critical for oxygen delivery to the brain via hemoglobin; supports mitochondrial function and energy production
Mitochondrial Support	Magnesium	ADHD, Anxiety & GAD, Depression & MDD, Alzheimer's Disease, Bipolar Disorder	Supports enzymes involved in glycolysis and the Krebs cycle (processes that generate ATP from glucose); binds to ATP and all triphosphates in cells to activate them
Mitochondrial Support	Manganese	ADHD, Anxiety & GAD, Depression & MDD, Alzheimer's Disease, Bipolar Disorder	Supports mitochondrial antioxidant defense through MnSOD activity
Mitochondrial Support	Vitamin B1 (Thiamine)	ADHD, Anxiety & GAD, Depression & MDD, Alzheimer's Disease, Bipolar Disorder	Essential for mitochondrial glucose metabolism in the brain leading to ATP production; supports PDH (pyruvate dehydrogenase) and α-KGDH (alpha-ketoglutarate dehydrogenase) function
Neurochemical Balance	Iron	ADHD, Anxiety & GAD, Depression & MDD, Alzheimer's Disease, Bipolar Disorder	Essential cofactor for tyrosine hydroxylase, the rate-limiting enzyme in the conversion of tyrosine to dopamine; critical for catecholamine synthesis
Neurochemical Balance	Magnesium	ADHD, Anxiety & GAD, Depression & MDD, Alzheimer's Disease, Bipolar Disorder	Broad cofactor for neurotransmitter synthesis and receptor modulation (e.g., NMDA, GABA); functions as an NMDA receptor antagonist and GABA receptor modulator; assists enzymes involved in synthesis of dopamine and serotonin
Neurochemical Balance	Phenylalanine	ADHD, Anxiety & GAD, Depression & MDD, Alzheimer's Disease, Bipolar Disorder	Essential amino acid that converts to tyrosine and supports catecholamine synthesis (dopamine, norepinephrine); participates in LAT1 competition at the blood-brain barrier
Neurochemical Balance	Tryptophan	ADHD, Anxiety & GAD, Depression & MDD, Alzheimer's Disease, Bipolar Disorder	Precursor for serotonin and melatonin; brain entry competes at LAT1 with other large neutral amino acids (LNAAs); carbohydrate-rich, low-protein meals raise the plasma tryptophan:LNAA ratio because insulin pushes competing LNAAs out to muscles; can feed NAD+ synthesis via the kynurenine pathway
Neurochemical Balance	Vitamin B6 (Pyridoxine → PLP)	ADHD, Anxiety & GAD, Depression & MDD, Alzheimer's Disease, Bipolar Disorder	Cofactor for synthesis of dopamine, serotonin, GABA, and glutamate; supports rate-limiting steps in catecholamine synthesis; requires PDXK activation with magnesium and ATP support
Neurochemical Balance	Zinc	ADHD, Anxiety & GAD, Depression & MDD, Alzheimer's Disease, Bipolar Disorder	Important for DNA synthesis, cell division, and neurotransmitter regulation, particularly in modulating dopamine—a key neurotransmitter implicated in ADHD; acts as an allosteric modulator of the GABA receptor; supports glutamate regulation
Oxidative Stress	Manganese	ADHD, Anxiety & GAD, Depression & MDD, Alzheimer's Disease, Bipolar Disorder	Essential cofactor for MnSOD (SOD2), supporting detoxification of superoxide within the mitochondrial matrix
Oxidative Stress	Zinc	ADHD, Anxiety & GAD, Depression & MDD, Alzheimer's Disease, Bipolar Disorder	Essential mineral that serves as a cofactor for antioxidant enzymes; works synergistically with other antioxidants; heavy metals are detoxified by metallothionein (MT) metal carrier proteins that must bind with zinc and copper
Stress Response	Magnesium	ADHD, Anxiety & GAD, Depression & MDD	Helps manage stress responses; combined with vitamin D reduced behavioral problems; synergy with zinc and omega-3s reported

References

• Beta-glucans: Prebiotic fiber for gut microbiome; food sources include oats, barley, mushrooms
• Tryptophan: Converted to NAD+ via kynurenine pathway; food sources include turkey, chicken, eggs, pumpkin seeds, oats, soybeans
• Serotonin: Mood regulation, emotional control, impulse moderation; food sources include turkey, eggs, dairy, soy, seeds, oats, bananas
• Tryptophan + complex carbohydrates aid serotonin conversion to melatonin; examples include pumpkin seeds + oats
• Soluble fibre (from apples, oats, flaxseeds) supports gut health and SCFA production
• Clinical trials have shown a doubling of plasma levels after dietary increases in oat bran due to its rich phosphatidylethanolamine (PE) content Sean Davies 2018
• Grain-legume complementarity: Grains (typically lysine-limited) and legumes (methionine/cysteine-limited) complete each other's profiles when paired, improving essential amino-acid coverage