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Methionine

Methionine structure

Overview​

Methionine is an essential amino acid that plays a central role in methylation processes. It forms S-adenosylmethionine (SAMe), the universal methyl donor that fuels neurotransmitter synthesis (dopamine, norepinephrine, serotonin) and drives phospholipid methylation in neuronal membranes. Methionine is converted to SAMe through a process that involves B vitamins (B6, B2, folate, B12) as cofactors. After donating its methyl group, SAMe becomes S-adenosylhomocysteine, which is then converted to homocysteine, which can be remethylated back to methionine in a cycle that requires adequate B vitamin status.

Recipes​

no recipes found (no foods contain this substance)

Foods​

no foods found

Biological Mechanisms and Implications​

No biological targets found for substance: Methionine

References​

  • Methionine is essential and forms SAMe, the universal methyl donor for neurotransmitter synthesis and membrane phospholipid methylation
  • B vitamins, particularly B6, B2, folate (5-MTHF), and B12, are essential cofactors in remethylation of homocysteine to methionine, which is converted to SAMe