Pomegranates

Overview

Pomegranates provide ellagitannins that gut bacteria convert to urolithin A, supporting mitochondrial resilience, mitophagy, and cognitive function. The Green Mediterranean Diet study showed greater visceral adipose tissue loss that tracked with higher total plasma polyphenols and with the microbiome-derived markers urolithin A (via ellagitannins: walnuts/pomegranate). Higher polyphenol intake and microbial diversity increase urolithin A and related metabolites, supporting mitochondrial resilience and mitophagy and improving cognitive endurance.

Recipes

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Substances

2 substances in this food

Potassium

Electrolyte for nerve transmission, muscle function, and blood pressure regulation

Vitamin C (Ascorbate)

Antioxidant; supports iron absorption; neuronal SVCT2 transport

Preparation Notes

• Consume whole fruit or juice to obtain ellagitannins
• Production of urolithin A depends on gut microbiome diversity; higher polyphenol intake and microbial diversity increase urolithin A production
• Pair with diverse plant foods to support microbiome; dietary diversity (≥30 plant foods per week) supports microbial richness and resilience
• Part of polyphenol-rich dietary pattern; polyphenol sources including berries, green tea catechins, cocoa flavanols, cranberries, pomegranate support gut microbiome health

Biological Target Matrix

Biological Target	Substance	Therapeutic Areas	Mechanism of Action
Hormonal Response	Vitamin C (Ascorbate)	ADHD, Anxiety & GAD	Supports norepinephrine synthesis as cofactor
Inflammation	Vitamin C (Ascorbate)	ADHD, Anxiety & GAD, Depression & MDD, Alzheimer's Disease, Bipolar Disorder	Antioxidant properties; supports anti-inflammatory effects
Neurochemical Balance	Potassium	ADHD, Anxiety & GAD, Depression & MDD, Alzheimer's Disease, Bipolar Disorder	Critical for membrane potential, nerve signaling, and neuronal excitability; adequate intake balances sodium effects
Neurochemical Balance	Vitamin C (Ascorbate)	ADHD, Anxiety & GAD, Depression & MDD, Alzheimer's Disease, Bipolar Disorder	Supports norepinephrine synthesis; transported in brain via SVCT2
Oxidative Stress	Vitamin C (Ascorbate)	ADHD, Anxiety & GAD, Depression & MDD, Alzheimer's Disease, Bipolar Disorder	Key water-soluble antioxidant; works within antioxidant network with vitamin E, CoQ10, and polyphenols
Stress Response	Vitamin C (Ascorbate)	ADHD, Anxiety & GAD, Depression & MDD	Supports stress response through antioxidant and neurochemical effects

References

• Polyphenol Sources: Berries, green tea catechins, cocoa flavanols, cranberries, pomegranate; ↑ Faecalibacterium, Roseburia; inhibit Enterobacteriaceae; reduce NF-κB activation
• The Green Mediterranean Diet study showed greater visceral adipose tissue loss that tracked with higher total plasma polyphenols and with the microbiome-derived markers urolithin A (via ellagitannins: walnuts/pomegranate) Zelicha et al. 2022
• Higher polyphenol intake and microbial diversity increase urolithin A and related metabolites, supporting mitochondrial resilience and mitophagy and improving cognitive endurance
• Urolithin A supports mitochondrial resilience and mitophagy, improving cognitive endurance Andreux et al. 2019 Singh et al. 2022