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Phosphatidylethanolamine (PE)

Overview​

Phosphatidylethanolamine (PE) is a key brain phospholipid that serves as a precursor to both phosphatidylcholine (PC) and N-acyl phosphatidylethanolamines (NAPEs). NAPEs are precursors to N-acyl ethanolamines (NAEs) including palmitoylethanolamide (PEA), oleoylethanolamide (OEA), and anandamide (AEA), which are bioactive lipids that act as neuromodulators with anti-inflammatory, neuroprotective, and mood-regulating effects. PE is a potential ADHD biomarker and supporting NAPEs production through diet via PE-rich foods like eggs, fish roe, liver, and oat bran may enhance endocannabinoid system tone.

Recipes​

2 recipes containing this substance

Chocolate Quinoa Crisp Clusters

A delicious cereal-to-snack hybrid with satisfying crunch, steady energy, and a low glycemic profile. Perfect for breakfast or anytime snacking.

Foods​

2 foods containing this substance

Eggs

Complete protein with choline, B vitamins, and phospholipids

Oats

Beta-glucans, tryptophan, and B vitamins for gut and neurotransmitter support

Biological Mechanisms and Implications​

No biological targets found for substance: Phosphatidylethanolamine

References​

  • PE is a key brain phospholipid and potential ADHD biomarker; can convert to PC or N-acyl phosphatidylethanolamines (NAPEs)
  • NAPEs are precursors to N-acyl ethanolamines (NAEs) like PEA, OEA, and anandamide, bioactive lipids with anti-inflammatory, neuroprotective, and mood-regulating effects
  • Supporting NAPEs production through diet via PE-rich foods like eggs, fish roe, and liver may enhance endocannabinoid system tone
  • Clinical trials have shown a doubling of plasma levels after dietary increases in oat bran due to its rich PE content Sean Davies 2018