Phosphatidylethanolamine (PE)
Overview
Phosphatidylethanolamine (PE) is a key brain phospholipid that serves as a precursor to both phosphatidylcholine (PC) and N-acyl phosphatidylethanolamines (NAPEs). NAPEs are precursors to N-acyl ethanolamines (NAEs) including palmitoylethanolamide (PEA), oleoylethanolamide (OEA), and anandamide (AEA), which are bioactive lipids that act as neuromodulators with anti-inflammatory, neuroprotective, and mood-regulating effects. PE is a potential ADHD biomarker and supporting NAPEs production through diet via PE-rich foods like eggs, fish roe, liver, and oat bran may enhance endocannabinoid system tone.
Recipes
1 recipe containing this substance
Chocolate Quinoa Crisp Clusters
A delicious cereal-to-snack hybrid with satisfying crunch, steady energy, and a low glycemic profile. Perfect for breakfast or anytime snacking.
Foods
Biological Mechanisms and Implications
| Biological Target | Therapeutic Areas | Mechanism of Action |
|---|---|---|
| Endocannabinoid System (ECS) | Key brain phospholipid that can convert to PC or N-acyl phosphatidylethanolamines (NAPEs); NAPEs are precursors to N-acyl ethanolamines (NAEs) like palmitoylethanolamide (PEA), oleoylethanolamide (OEA), and anandamide (AEA), bioactive lipids which act as neuromodulators with anti-inflammatory, neuroprotective, and mood-regulating effects |
References
- PE is a key brain phospholipid and potential ADHD biomarker; can convert to PC or N-acyl phosphatidylethanolamines (NAPEs)
- NAPEs are precursors to N-acyl ethanolamines (NAEs) like PEA, OEA, and anandamide, bioactive lipids with anti-inflammatory, neuroprotective, and mood-regulating effects
- Supporting NAPEs production through diet via PE-rich foods like eggs, fish roe, and liver may enhance endocannabinoid system tone
- Clinical trials have shown a doubling of plasma levels after dietary increases in oat bran due to its rich PE content Sean Davies 2018