Fish Roe
Overview
Fish roe provides phospholipid-bound omega-3 fatty acids (EPA/DHA), astaxanthin, and other nutrients in highly bioavailable forms for brain health. Salmon and other roe provide phospholipid-bound omega-3s for superior brain delivery.
Recipes
Substances
3 substances in this food
DHA (Docosahexaenoic Acid)
Accounts for ~10–15% of total brain fatty acids, 20–30% of neuronal phospholipids (PE, PS), and >90% of brain omega-3 PUFA; critical for membrane fluidity, synaptic vesicle fusion, neurodevelopment
EPA (Eicosapentaenoic Acid)
Potent anti-inflammatory; precursor to E-series resolvins; modulates dopamine and serotonin signalling
Phosphatidylcholine (PC)
Key brain phospholipid; carrier for DHA/EPA and acetylcholine precursor pathway
Preparation Notes
- Phospholipid-bound omega-3s for superior brain delivery
- Astaxanthin for antioxidant support
- High bioavailability compared to triglyceride forms
- Supports LPC-DHA transport across blood-brain barrier
Biological Target Matrix
| Biological Target | Substance | Therapeutic Areas | Mechanism of Action |
|---|---|---|---|
| Endocannabinoid System (ECS) | DHA (Docosahexaenoic Acid) | Production of docosahexaenoyl ethanolamide (DHEA), an N-acyl ethanolamine for endocannabinoid-like signaling | |
| Endocannabinoid System (ECS) | EPA (Eicosapentaenoic Acid) | Production of eicosapentaenoyl ethanolamide (EPEA), an N-acyl ethanolamine for endocannabinoid-like signaling | |
| Endocannabinoid System (ECS) | Omega-3 Fatty Acids | Production of docosahexaenoyl ethanolamide (DHEA) and eicosapentaenoyl ethanolamide (EPEA), N-acyl ethanolamines for endocannabinoid-like signaling | |
| Hormonal Response | Omega-3 Fatty Acids | Support hormonal balance through membrane integrity and anti-inflammatory effects | |
| Inflammation | DHA (Docosahexaenoic Acid) | Precursor to specialized pro-resolving mediators (SPMs) including protectins and maresins; terminates inflammation without immunosuppression | |
| Inflammation | EPA (Eicosapentaenoic Acid) | Potent anti-inflammatory; precursor to E-series resolvins; specialized pro-resolving mediators (SPMs) terminate inflammation without immunosuppression, downregulate COX-2, inhibit neutrophil infiltration, enhance macrophage clearance | |
| Inflammation | Omega-3 Fatty Acids | Specialized Pro-Resolving Mediators (SPMs) - resolvins, protectins, maresins terminate inflammation without immunosuppression, downregulate COX-2, inhibit neutrophil infiltration, enhance macrophage clearance, limit glutamate-induced excitotoxicity | |
| Methylation | Omega-3 Fatty Acids | Support homocysteine reduction in combination with B12, phospholipid methylation (PLM) dependent on SAMe | |
| Neurochemical Balance | DHA (Docosahexaenoic Acid) | Accounts for ~10–15% of total brain fatty acids, but represents 20–30% of fatty acids in neuronal phospholipids such as PE and PS, and more than 90% of the brain's omega-3 PUFA; critical for membrane fluidity, synaptic vesicle fusion, and neurodevelopment; transported across BBB as LPC-DHA via MFSD2A | |
| Neurochemical Balance | EPA (Eicosapentaenoic Acid) | Modulates dopamine and serotonin signalling; synergises with DHA but has independent mechanisms; membrane fluidity and neurotransmitter receptor function | |
| Neurochemical Balance | Omega-3 Fatty Acids | Membrane fluidity and neurotransmitter receptor function, ion channel behavior and gamma oscillations, support neurotransmission and phospholipid methylation | |
| Neurochemical Balance | Phosphatidylcholine (PC) | Major neuronal membrane phospholipid central to membrane fluidity, receptor function, and acetylcholine synthesis; DHA/EPA incorporated into PC are converted to lysophosphatidylcholine (LPC), a key transport form across the BBB | |
| Oxidative Stress | Omega-3 Fatty Acids | — | |
| Stress Response | Omega-3 Fatty Acids | Improve vagal tone and HRV control, improve cortisol rhythms |
References
- Salmon and other roe provide phospholipid-bound omega-3s for superior brain delivery
- Targeted foods such as salmon or lumpfish roe can be used to reliably and safely exceed minimum omega-3 intakes, helping individuals achieve optimal omega-3 status for brain health, cognitive performance, and inflammatory regulation