Grapes

Overview

Grapes provide resveratrol, a polyphenol that activates SIRT1, enhancing NAD+-dependent processes and supporting mitochondrial function.

Within the BRAIN Diet framework, polyphenols (e.g., resveratrol) activate SIRT1, enhancing NAD⁺-dependent processes, and are found in grapes, blueberries, cranberries, peanuts, and dark chocolate [1][2].

Key Nutritional Highlights

• Polyphenol-rich fruit patterns are associated with cognitive endpoints in flavonoid intervention trials [1]
• Grape polyphenols such as resveratrol are studied for antioxidant and nutraceutical mechanisms [2]
• Grapes provide resveratrol, a polyphenol that activates SIRT1, enhancing NAD+-dependent processes and supporting mitochondrial function. [1]
• Polyphenols (e.g., resveratrol) activate SIRT1, enhancing NAD⁺-dependent processes, and are found in grapes, blueberries, cranberries, peanuts, and dark chocolate. [2]
• Grapes provide resveratrol, a polyphenol that activates SIRT1, enhancing NAD+-dependent processes and supporting mitochondrial function.

Food Context

Synergies

• Part of diverse polyphenol intake
• Pair with other resveratrol sources

Preparation

• Can be consumed fresh or as juice (whole fruit preferred)
• Supports mitochondrial NAD+ pathways

Recipes

no recipes found

Nutrient Tables (per 100 g)

Core nutrients

Nutrient	Amount per 100 g	% RDA per 100 g
Energy	71.9 kcal	—
Protein	0.9 g	—
Total fat	0.2 g	—
Carbohydrates	18.6 g	—
Sugars	16.1 g	—

Key micronutrients

Nutrient	Amount per 100 g	% RDA per 100 g
Iron	0.2 mg	1.1%
Zinc	0 mg	0.2%
Magnesium	7.1 mg	1.7%
Calcium	9.9 mg	1%
Potassium	218.1 mg	6.4%

Reference intakes: US Dietary Reference Intakes for adults (19–50 years; using the higher of male/female values where they differ).

Data provenance (core / micronutrient panel): USDA FoodData Central, Grapes, green, seedless, raw, FDC ID 2346413, API, per 100 g edible portion, last checked 2026-03-14

Substances

Substances in this food: editorial (Overview / literature) plus analytical (nutrition table).

5 substances in this food

K⁺

Potassium

Electrolyte for nerve transmission, muscle function, and blood pressure regulation

Fe²⁺

Iron

Oxygen transport; dopamine synthesis (tyrosine hydroxylase cofactor)

Zn²⁺

Zinc

Cofactor in neurotransmission and antioxidant enzymes; dopamine modulation

Mg²⁺

Magnesium

Enzymatic cofactor (>300 reactions); neurotransmitters; mitochondria; redox balance

Ca²⁺

Calcium

Bone health; neurotransmission; interacts with vitamin D and K2

References

[1] Polyphenol-rich fruit patterns are associated with cognitive endpoints in flavonoid intervention trials. Neshatdoust et al. 2016. High-flavonoid intake induces cognitive improvements linked to changes in serum brain-derived neurotrophic factor: Two randomised, controlled trials

[2] Grape polyphenols such as resveratrol are studied for antioxidant and nutraceutical mechanisms. Boots et al. 2008. Health effects of quercetin: From antioxidant to nutraceutical