Betaine
Trimethylglycine in beets, spinach, wheat germ and quinoa; methyl donor for BHMT, with brain effects not yet established.
Trimethylglycine in beets, spinach, wheat germ and quinoa; methyl donor for BHMT, with brain effects not yet established.
Essential methyl-donor nutrient in eggs, meat and milk; mapped to BRS2 one-carbon metabolism and BRS6 hepatic lipid export.
Conditionally essential amino acid; precursor for creatine and nitric oxide synthesis
Non-protein amino acid that contributes to arginine and nitric oxide pathway context
Sulfur amino acid made from methionine. Food tables report cystine. Mapped to glutathione assembly with the formula-diet limits.
Amino acid and the substrate of GAD and of the first step of glutathione assembly. Intracellular roles are not a requirement to eat glutamate.
Amino acid used by enterocytes. Adult trials do not show a general permeability benefit. A postinfectious IBS supplement result stays in that group.
Nonessential amino acid in collagen-rich foods. Substrate of glutathione assembly. Trials of glycine taken alone report psychiatric-symptom changes and small, high-bias sleep findings.
Amino acid condensed with homocysteine by cystathionine beta-synthase. Diet and endogenous synthesis can both supply it.
Dopamine and norepinephrine precursor; LAT1 competition with LNAAs
Essential AA; precursor to histamine; roles in enzyme active sites
Essential BCAA; energy metabolism; complements leucine/valine
Essential BCAA; mTOR signaling; protein synthesis; cognitive load support
Essential AA; limiting in many cereals; complements legumes
Essential AA; precursor to SAMe via methylation cycle
Essential AA; precursor to tyrosine → catecholamines
Essential AA; structural proteins; mucin production
Serotonin/melatonin precursor; NAD+ pathway substrate; LAT1 transport dynamics
Essential BCAA; supports protein balance and neurotransmitter transport competition
A branched α-L-arabinofuranose polysaccharide and a neutral side chain of pectin. Local evidence is one pea-fibre arabinan, not every arabinan source.
The studied combined oligosaccharide preparation. Its fermentation result is not evidence for either class alone, and it is not oligofructose.
A class of plant cell-wall polysaccharides. Apple pectin, citrus pectin, and generic fermentation substrates are separate evidence records.
Starch that escapes small-intestinal digestion. Type 2 mouse feeding, resistant potato starch, and RS2/RS3 cultures are separate exposures.
Longer-chain inulin-type fructan. The mouse mucus result used oligofructose-enriched inulin, which is not inulin alone and not oligofructose alone.
Short-chain inulin-type fructan mixture. FOS and fructooligosaccharides overlap with this name but are not exact synonyms.
The sugar used as a luminal sensory stimulus in a mouse neuropod–vagal circuit. That experiment is not a reason to eat more glucose.
Principal dietary monounsaturated fatty acid (18:1 n-9); not synonymous with MUFA or omega-9
Key brain phospholipid; carrier for DHA/EPA and acetylcholine precursor pathway
Brain phospholipid; precursor to PC and NAPE → NAEs (PEA/OEA/AEA)
Neuronal membrane phospholipid; cognition; stress modulation
Essential omega-3 precursor; limited conversion to DHA/EPA
Accounts for ~10–15% of total brain fatty acids, 20–30% of neuronal phospholipids (PE, PS), and >90% of brain omega-3 PUFA; critical for membrane fluidity, synaptic vesicle fusion, neurodevelopment
The "intermediate" between EPA ↔ DHA; important in vascular health, repair, and immune modulation
Potent anti-inflammatory; precursor to E-series resolvins; modulates dopamine and serotonin signalling
(EPA, DHA) Anti-inflammatory, membrane, and neuromodulatory lipids central to BRAIN Diet
Omega-6 PUFA; eicosanoid precursor; balance with omega-3s
Essential omega-6; precursor to arachidonic acid and eicosanoids
Medium-chain triglyceride (C10) providing rapid brain energy via ketone production
Medium-chain triglyceride (C6) providing rapid brain energy via ketone production
Medium-chain triglyceride (C8) providing rapid brain energy via ketone production
Medium-chain fatty acids (C8, C10) providing rapid brain energy via ketone production
Bone health; neurotransmission; interacts with vitamin D and K2
Enzymatic cofactor (>300 reactions); neurotransmitters; mitochondria; redox balance
Structural phosphate in ATP, phosphocreatine, phospholipids, DNA/RNA, and signalling
Electrolyte for nerve transmission, muscle function, and blood pressure regulation
Electrolyte for fluid balance and nerve function
Ultratrace mineral; bone, hormone, and vitamin D metabolism support
Trivalent chromium; insulin signalling and glucose handling support
Essential cuproenzyme cofactor for catecholamine synthesis, iron efflux and redox defence; mapped to BRS1, BRS3, BRS5 and BRS6.
Thyroid hormone synthesis; neurodevelopment; neurotransmitter regulation
Oxygen transport; dopamine synthesis (tyrosine hydroxylase cofactor)
Cofactor for MnSOD (SOD2); mitochondrial antioxidant defense
Antioxidant enzyme cofactor (GPx); supports redox balance
Cofactor in neurotransmission and antioxidant enzymes; dopamine modulation
A reduced form of vitamin B9 in foods, and the methyl donor for homocysteine remethylation.
The riboflavin-derived cofactor that accepts NADH electrons at the start of mitochondrial complex I.
All-trans-retinoic acid made in the body from dietary retinol or beta-carotene, not stored in the food.
Neurodevelopment; immune regulation; antioxidant via carotenoids
Mitochondrial glucose metabolism; ATP synthesis; rapid turnover in CNS
Methylation; myelin; mitochondrial odd-chain FA metabolism
Flavin mononucleotide (FMN) and FAD coenzymes; redox balance; supports methylation via MTHFR
NAD+ precursor; supports mitochondrial biogenesis and ATP production
CoA synthesis; fatty-acid oxidation; TCA cycle flux
PLP cofactor for neurotransmitter synthesis; relies on brain PDXK activation
One-carbon metabolism; methylation; homocysteine recycling
Antioxidant; supports iron absorption; neuronal SVCT2 transport
Neurotrophic and immune modulation; calcium homeostasis
Lipid-phase antioxidant; protects PUFA (DHA) in membranes
Phylloquinone (vitamin K1) from green plants; required for vitamin K–dependent carboxylation.
Calcium handling; potential roles in brain health; often co-occurs with fat-soluble vitamins