Arginine
Conditionally essential amino acid; precursor for creatine and nitric oxide synthesis
Conditionally essential amino acid; precursor for creatine and nitric oxide synthesis
Nonessential amino acid; inhibitory neurotransmitter; supports sleep, gut barrier repair, and glutathione production
Dopamine and norepinephrine precursor; LAT1 competition with LNAAs
Essential AA; precursor to histamine; roles in enzyme active sites
Essential BCAA; energy metabolism; complements leucine/valine
Essential BCAA; mTOR signaling; protein synthesis; cognitive load support
Essential AA; limiting in many cereals; complements legumes
Essential AA; precursor to SAMe via methylation cycle
Essential AA; precursor to tyrosine → catecholamines
Essential AA; structural proteins; mucin production
Serotonin/melatonin precursor; NAD+ pathway substrate; LAT1 transport dynamics
Essential BCAA; supports protein balance and neurotransmitter transport competition
Key brain phospholipid; carrier for DHA/EPA and acetylcholine precursor pathway
Brain phospholipid; precursor to PC and NAPE → NAEs (PEA/OEA/AEA)
Neuronal membrane phospholipid; cognition; stress modulation
Essential omega-3 precursor; limited conversion to DHA/EPA
Accounts for ~10–15% of total brain fatty acids, 20–30% of neuronal phospholipids (PE, PS), and >90% of brain omega-3 PUFA; critical for membrane fluidity, synaptic vesicle fusion, neurodevelopment
The "intermediate" between EPA ↔ DHA; important in vascular health, repair, and immune modulation
Potent anti-inflammatory; precursor to E-series resolvins; modulates dopamine and serotonin signalling
(EPA, DHA) Anti-inflammatory, membrane, and neuromodulatory lipids central to BRAIN Diet
Omega-6 PUFA; eicosanoid precursor; balance with omega-3s
Essential omega-6; precursor to arachidonic acid and eicosanoids
Medium-chain triglyceride (C10) providing rapid brain energy via ketone production
Medium-chain triglyceride (C6) providing rapid brain energy via ketone production
Medium-chain triglyceride (C8) providing rapid brain energy via ketone production
Medium-chain fatty acids (C8, C10) providing rapid brain energy via ketone production
Bone health; neurotransmission; interacts with vitamin D and K2
Enzymatic cofactor (>300 reactions); neurotransmitters; mitochondria; redox balance
Electrolyte for nerve transmission, muscle function, and blood pressure regulation
Electrolyte for fluid balance and nerve function
Cofactor in redox enzymes; dopamine β-hydroxylase; iron metabolism interplay
Thyroid hormone synthesis; neurodevelopment; neurotransmitter regulation
Oxygen transport; dopamine synthesis (tyrosine hydroxylase cofactor)
Cofactor for MnSOD (SOD2); mitochondrial antioxidant defense
Antioxidant enzyme cofactor (GPx); supports redox balance
Cofactor in neurotransmission and antioxidant enzymes; dopamine modulation
Neurodevelopment; immune regulation; antioxidant via carotenoids
Mitochondrial glucose metabolism; ATP synthesis; rapid turnover in CNS
Methylation; myelin; mitochondrial odd-chain FA metabolism
FMN/FAD coenzymes; redox balance; supports methylation via MTHFR
NAD+ precursor; supports mitochondrial biogenesis and ATP production
CoA synthesis; fatty-acid oxidation; TCA cycle flux
PLP cofactor for neurotransmitter synthesis; relies on brain PDXK activation
One-carbon metabolism; methylation; homocysteine recycling
Antioxidant; supports iron absorption; neuronal SVCT2 transport
Neurotrophic and immune modulation; calcium homeostasis
Lipid-phase antioxidant; protects PUFA (DHA) in membranes
Calcium handling; potential roles in brain health; often co-occurs with fat-soluble vitamins