Arginine

Overview
Arginine is a conditionally essential amino acid that supports nitric oxide production and endogenous creatine synthesis. Along with glycine and methionine, arginine contributes to creatine-pathway substrate supply, while nitric oxide signaling supports vascular tone and cerebral blood-flow regulation.
Food context matters: arginine-rich foods are mainly high-protein animal foods and selected plant proteins (especially seeds, soy foods, and lupin beans), not trace-presence foods. Nori contains arginine but is typically consumed in small portions and is not a high practical source compared with meats, fish, or dense plant proteins.
Top Food Sources (Practical)
Animal (top links)
Vegetarian (top links)
Minor contributor
- Nori (contains arginine but is usually consumed in small portions)
Recipes
Foods
Biological Mechanisms and Implications
References
- Arginine is a precursor for creatine synthesis (along with glycine and methionine); creatine supports ATP recycling via the phosphocreatine system in neurons.
- Arginine is a precursor for nitric oxide synthesis, supporting vascular function and cerebral blood-flow context.
- Practical dietary arginine supply is dominated by high-protein animal foods and dense plant proteins (seeds, soy foods, legumes), while trace-presence foods such as nori contribute less at typical servings.
Foods supply the named dietary input. They are not shown as containing the downstream metabolite. Conversion evidence does not establish a new downstream PM admission, effective dose or equivalent food intervention.
Arginine → Human AGAT transfers the amidino group of arginine to glycine, yielding guanidinoacetate and ornithine. → Guanidinoacetate
BRS4-FM1-PM3: Enable rapid ATP buffering so high-energy-demand tissues can meet sudden metabolic spikes.
Existing admission: Type A / derived; versioned-assessment. Production context for an already admitted substrate; no new metabolite-to-PM relationship is admitted.
Capacity of the endogenous synthesis route is distinct from a claim that extra amino-acid intake raises cerebral creatine, phosphocreatine buffering or cognition. AGAT feedback, GAMT methyl supply, organ exchange and SLC6A8-mediated tissue transport constrain delivery. Human renal GAA production is not a measurement of brain synthesis flux; rat arginine infusion and glycine null responses are not oral human efficacy experiments.
- Lupin Beans — supplies Arginine; verified; raw. Lupins, mature seeds, raw
Composition provenance
USDA SR Legacy April 2018
- Watermelon — supplies Arginine; verified; raw. Watermelon, raw
Composition provenance
USDA SR Legacy April 2018
Both co-substrates are required; this is not a fixed dietary yield or an assertion that extra intake is rate-limiting.
Dependencies: Functional AGAT; glycine co-substrate availability; Tissue access and feedback regulation
Arginine → Human AGAT transfers the amidino group of arginine to glycine, yielding guanidinoacetate and ornithine. → GAMT methylates guanidinoacetate using S-adenosylmethionine to form creatine. → Creatine
BRS4-FM1-PM3: Enable rapid ATP buffering so high-energy-demand tissues can meet sudden metabolic spikes.
Existing admission: Type A / derived; versioned-assessment. The complete derived relationship is admitted for this PM.
Capacity of the endogenous synthesis route is distinct from a claim that extra amino-acid intake raises cerebral creatine, phosphocreatine buffering or cognition. AGAT feedback, GAMT methyl supply, organ exchange and SLC6A8-mediated tissue transport constrain delivery. Human renal GAA production is not a measurement of brain synthesis flux; rat arginine infusion and glycine null responses are not oral human efficacy experiments.
- Lupin Beans — supplies Arginine; verified; raw. Lupins, mature seeds, raw
Composition provenance
USDA SR Legacy April 2018
- Watermelon — supplies Arginine; verified; raw. Watermelon, raw
Composition provenance
USDA SR Legacy April 2018
Both co-substrates are required; this is not a fixed dietary yield or an assertion that extra intake is rate-limiting.
Dependencies: Functional AGAT; glycine co-substrate availability; Tissue access and feedback regulation
Reaction identity does not prove dietary precursor limitation or cerebral delivery; SAM participation creates no independent methionine admission.
Dependencies: Functional GAMT; S-adenosylmethionine methyl supply; Interorgan exchange and receiving-tissue creatine transport
Arginine → Human AGAT transfers the amidino group of arginine to glycine, yielding guanidinoacetate and ornithine. → GAMT methylates guanidinoacetate using S-adenosylmethionine to form creatine. → Creatine
BRS4-FM1-PM3: Enable rapid ATP buffering so high-energy-demand tissues can meet sudden metabolic spikes.
Existing admission: Type A / derived; versioned-assessment. The complete derived relationship is admitted for this PM.
Capacity of the endogenous synthesis route is distinct from a claim that extra amino-acid intake raises cerebral creatine, phosphocreatine buffering or cognition. AGAT feedback, GAMT methyl supply, organ exchange and SLC6A8-mediated tissue transport constrain delivery. Human renal GAA production is not a measurement of brain synthesis flux; rat arginine infusion and glycine null responses are not oral human efficacy experiments.
- Lupin Beans — supplies Arginine; verified; raw. Lupins, mature seeds, raw
Composition provenance
USDA SR Legacy April 2018
- Watermelon — supplies Arginine; verified; raw. Watermelon, raw
Composition provenance
USDA SR Legacy April 2018
Both co-substrates are required; this is not a fixed dietary yield or an assertion that extra intake is rate-limiting.
Dependencies: Functional AGAT; glycine co-substrate availability; Tissue access and feedback regulation
Reaction identity does not prove dietary precursor limitation or cerebral delivery; SAM participation creates no independent methionine admission.
Dependencies: Functional GAMT; S-adenosylmethionine methyl supply; Interorgan exchange and receiving-tissue creatine transport