Linoleic Acid (LA, n-6)
Overview
Linoleic acid (LA) is an essential omega-6 fatty acid that the body cannot synthesize and must obtain from the diet. It serves as a precursor to arachidonic acid and various eicosanoids, which are signaling molecules involved in inflammation and immune function. While linoleic acid is essential, the balance between omega-6 and omega-3 fatty acids is important, as excessive n-6:n-3 ratios (common in Western diets) may skew toward pro-inflammatory eicosanoids. The BRAIN Diet emphasizes maintaining an appropriate balance between omega-6 and omega-3 fatty acids for optimal inflammatory tone and brain health.
Recipes
5 recipes containing this substance
Chocolate Quinoa Crisp Clusters
A delicious cereal-to-snack hybrid with satisfying crunch, steady energy, and a low glycemic profile. Perfect for breakfast or anytime snacking.
Ginger Yogurt and Blueberries
An Anti-inflammatory polyphenol-rich breakfast bowl with high fibre. Start the day with anti-inflammatory gingerols and omega 3 nuts, blueberry polyphenols, a fibre from steel rolled oats. Great to set up dopamine for focus and attention.
Matcha Mitochondria Smoothie
Mitochondrial energising smoothie rich in polyphenols, magnesium, and antioxidants
Mitochondrial Power Bowl
A nitrate-rich, polyphenol-dense bowl supporting mitochondrial function, ATP generation, and metabolic resilience
Rocket Lentil Avocado Midday Salad (Gut-Supporting)
Polyphenol-rich salad supporting SIRT1 activation and microbiome synchronisation
Foods
9 foods containing this substance
Almonds
Vitamin E, plant protein, and healthy fats
Cashews
Plant protein and zinc source
Chia Seeds
ALA omega-3, fiber, and minerals
Flax Seeds
ALA omega-3 and soluble fiber source
Peanuts
Niacin, resveratrol, and plant protein for NAD+ and mitochondrial support
Sunflower Seeds
Thiamine source and sunflower lecithin precursor
Tempeh
Fermented soy providing probiotics and enhanced nutrient bioavailability
Tofu
Soy-based protein source with isoflavones and choline
Walnuts
ALA omega-3, polyphenols, and ellagitannins for urolithin A production
Biological Mechanisms and Implications
| Biological Target | Therapeutic Areas | Mechanism of Action |
|---|---|---|
| Inflammation | Essential omega-6 fatty acid; precursor to arachidonic acid and eicosanoids; excessive n-6:n-3 ratios may skew toward pro-inflammatory eicosanoids | |
| Oxidative Stress | Essential fatty acid; balance with omega-3s is emphasized for optimal inflammatory tone |
References
- LA is an essential omega-6 fatty acid; excessive n-6:n-3 ratios may skew toward pro-inflammatory eicosanoids; balance with omega-3s is emphasized
- Western diets can skew n-6:n-3 ratio as high as 20:1, contributing to chronic inflammation and neurotransmitter dysregulation Simopoulos 2011
- Overall dietary n-6:n-3 balance affects inflammatory tone