Selenium
Se2-
Overview
Selenium is an essential trace mineral that functions as a critical cofactor for glutathione peroxidase (GPx) and other antioxidant enzymes. These selenium-dependent enzymes protect cell membranes and mitochondria from oxidative damage by neutralizing harmful reactive oxygen species. Selenium works within the broader antioxidant network, supporting redox balance and protecting against oxidative stress that can impair brain function. Adequate selenium intake is important for maintaining antioxidant defenses, particularly in tissues with high metabolic activity like the brain.
Dietary absorption and meal context
- Food distribution: Selenium content in foods varies substantially by soil and feed conditions, so food composition can differ across regions.
- Food-first strategy: Seafood, eggs, meats, and moderate portions of selenium-rich nuts can support adequacy.
- Practical caution: Avoid frequent high-dose intake because selenium has a narrower safety margin than many other minerals.
Recipes
Foods
Biological Mechanisms and Implications
References
- Selenium supports glutathione peroxidase and other antioxidant systems, protecting membranes and mitochondria from oxidative damage
- Included among trace minerals essential for antioxidant networks




