Mitochondrial Function & Bioenergetics
Capacity layer — ATP production, metabolic resilience, oxidative phosphorylation efficiency
Capacity layer — ATP production, metabolic resilience, oxidative phosphorylation efficiency
Mitochondrial energising smoothie rich in polyphenols, magnesium, and antioxidants
A warm savoury breakfast skillet with eggs, greens, and slow carbohydrates for steady morning energy.
A fibre-rich bean and vegetable chilli with warming spices and slow carbohydrates for steady energy and satiety.
Whole-wheat linguine with cockles in a silky emulsified sauce; Italian emulsification technique without cream, supporting taurine, B12, and choline intake.
A nitrate-rich, polyphenol-dense bowl combining leafy greens, beets, berries, nuts, and early harvest olive oil
Lipid-soluble carotenoid that stabilizes omega-3–rich membranes; supports mitochondrial and cellular resilience
Acetylcholine precursor; methyl donor; phospholipid synthesis for membranes
Electron transport chain cofactor and antioxidant relevant to mitochondrial function
Phosphocreatine system buffer for neuronal ATP demand; cognitive support evidence
Dietary nitrate that converts to nitric oxide, supporting vascular function and mitochondrial efficiency
Osmoregulator; GABA modulation; mitochondrial membrane stabilizer; anti-inflammatory
Polyphenol; antioxidant; mitochondrial support; bioavailability improved with vitamin C
Major secoiridoid polyphenol in olive oil; oleuropein aglycone supports mitophagy, SIRT1, and AMPK activation
Key SCFA supporting mitochondrial function, gut barrier integrity, and neuroinflammation reduction
Microbial metabolites supporting gut barrier, immune tone, and brain function
Microbiome-derived metabolite from ellagitannins; supports mitochondrial resilience and mitophagy
Conditionally essential amino acid; precursor for creatine and nitric oxide synthesis
Accounts for ~10–15% of total brain fatty acids, 20–30% of neuronal phospholipids (PE, PS), and >90% of brain omega-3 PUFA; critical for membrane fluidity, synaptic vesicle fusion, neurodevelopment
Potent anti-inflammatory; precursor to E-series resolvins; modulates dopamine and serotonin signalling
(EPA, DHA) Anti-inflammatory, membrane, and neuromodulatory lipids central to BRAIN Diet
Medium-chain triglyceride (C10) providing rapid brain energy via ketone production
Medium-chain triglyceride (C6) providing rapid brain energy via ketone production
Medium-chain triglyceride (C8) providing rapid brain energy via ketone production
Medium-chain fatty acids (C8, C10) providing rapid brain energy via ketone production
Enzymatic cofactor (>300 reactions); neurotransmitters; mitochondria; redox balance
Oxygen transport; dopamine synthesis (tyrosine hydroxylase cofactor)
Cofactor for MnSOD (SOD2); mitochondrial antioxidant defense
Antioxidant enzyme cofactor (GPx); supports redox balance
Mitochondrial glucose metabolism; ATP synthesis; rapid turnover in CNS
Methylation; myelin; mitochondrial odd-chain FA metabolism
FMN/FAD coenzymes; redox balance; supports methylation via MTHFR
NAD+ precursor; supports mitochondrial biogenesis and ATP production
CoA synthesis; fatty-acid oxidation; TCA cycle flux
Dietary strategies targeting inflammation, neurochemical balance, mitochondrial function, and gut-brain axis to support attention, focus, and executive function
Dietary interventions targeting mitochondrial function, oxidative stress, inflammation, and neurochemical balance to slow cognitive decline and support neuroprotection
Nutritional strategies targeting HPA axis regulation, stress response, neurochemical balance, and gut-brain communication to reduce anxiety and support emotional regulation
Nutritional approaches to support mood stability and cognitive function through modulation of neurotransmitter balance, mitochondrial health, and inflammatory pathways
Food-first dietary interventions targeting neurochemical balance, inflammation, gut-brain axis, and metabolic health to support mood regulation and emotional resilience