Berberine
Polyphenolic alkaloid; glycemic control; antimicrobial effects; microbiome modulation
Polyphenolic alkaloid; glycemic control; antimicrobial effects; microbiome modulation
Levodopa: a pharmacologically active precursor of dopamine
Calming amino acid from tea; increases alpha waves; sleep-friendly
Polysaccharides with immune-modulating properties found in mushrooms and other foods
Endogenous γ-glutamyl-cysteinyl-glycine tripeptide and GSH/GSSG redox resource pool; nutritionally relevant through precursor supply, synthesis and recycling rather than as a vitamin.
Supplemental cysteine precursor. The glutathione result used it together with glycine in older adults. It is not food cysteine.
Dietary nitrate that converts to nitric oxide, supporting vascular function and mitochondrial efficiency
Complex carbohydrates with immune-modulating and gut microbiome supporting properties
A dietary and endogenous polyamine studied in cellular recycling and mitochondrial maintenance; human cognitive benefit remains unestablished.
Osmoregulator; GABA modulation; mitochondrial membrane stabilizer; anti-inflammatory
Nucleoside that can supply CTP for CDP-choline. UMP and uridine-plus-DHA combinations are separate exposures.
Xanthophyll carotenoid in salmon, salmon roe, and related marine foods; mapped to BRS3 redox signalling and BRS4 mitochondrial membrane protection.
Neuroprotective carotenoid; vitamin A precursor; supports immune regulation and neuronal development
Neuroprotective carotenoid; accumulates in neural tissues and retina; supports cognitive performance
Neuroprotective carotenoid; found in tomatoes; absorption enhanced by cooking and dietary fat
Neuroprotective carotenoid; accumulates in neural tissues and retina; supports cognitive performance
Trimethylglycine in beets, spinach, wheat germ and quinoa; methyl donor for BHMT, with brain effects not yet established.
Essential methyl-donor nutrient in eggs, meat and milk; mapped to BRS2 one-carbon metabolism and BRS6 hepatic lipid export.
Principal sesame lignan; preliminary cardiometabolic trials, null food-level findings, and incomplete translation to ordinary servings.
Distinct sesame lignan with redox and neuroprotective laboratory findings and almost no human clinical evidence.
Electron transport chain cofactor and antioxidant relevant to mitochondrial function
Phosphocreatine system buffer for neuronal ATP demand; cognitive support evidence
Reactive organosulfur compound formed when garlic is crushed; linked to antioxidant and antimicrobial effects.
Glucosinolate precursor of sulforaphane, concentrated in broccoli sprouts.
Isothiocyanate formed from glucoraphanin when myrosinase is active; studied for Nrf2 signalling.
Glycosylated flavonoid pigments derived from anthocyanidin parent structures. Human evidence typically concerns anthocyanin-rich foods, mixed extracts, or specific glycosides rather than isolated anthocyanidin aglycones.
Anthocyanidin parent compound and its common dietary glycoside, cyanidin-3-glucoside (C3G).
Anthocyanidin parent compound; occurs in foods predominantly as glycosylated anthocyanins.
Anthocyanidin parent compound; occurs in foods predominantly as glycosylated derivatives, notably in red/purple grapes and blueberries.
Anthocyanidin parent compound; occurs in foods predominantly as glycosides and is the dominant anthocyanidin backbone in strawberries.
Anthocyanidin parent compound; occurs in foods predominantly as methylated anthocyanin glycosides, including in cherries, cranberries, and blueberries.
Anthocyanidin parent compound; occurs in foods predominantly as glycosylated anthocyanins, including in blueberries and red/purple grapes.
Anti-inflammatory, antioxidant; bioavailability enhanced with piperine and fats
Hydrolysable tannins that release ellagic acid. They are the upstream class, not ellagic acid and not urolithin A.
Cocoa flavanol monomer (a catechin); part of dark chocolate flavanol fraction.
Polyphenol; antioxidant; gut barrier/LPS modulation; supports microbiome
Cocoa flavanol monomer (a catechin); linked to vascular and cognitive endpoints.
Dark chocolate procyanidin oligomer fraction (flavanol oligomers); studied as part of total cocoa flavanol profile.
Lemon-associated citrus flavanone studied for antioxidant activity and flavanone metabolism.
Citrus flavanone glycoside (notably orange, also present in lemon) with cardiometabolic and vascular research interest.
Dietary flavonol in leafy greens, herbs, tea and some fruits; studied as a food constituent and as an isolated hormetic/senolytic agent.
Polyphenol; antioxidant; mitochondrial support; bioavailability improved with vitamin C
Soy isoflavone; ECS modulation via FAAH inhibition; anti-inflammatory/neuroprotective
The microbial substrate for urolithin formation. Conversion depends on the community and can stop at intermediates. It is not urolithin A.
Potent antioxidant polyphenol from extra-virgin olive oil; anti-inflammatory
Phenolic compound in olive oil; neuroprotective effects and precursor to hydroxytyrosol
Secoiridoid polyphenol in extra-virgin olive oil; antioxidant and NRF2 activation
Secoiridoid polyphenol in extra-virgin olive oil; NF-κB inhibition and anti-inflammatory effects
Major secoiridoid polyphenol in olive oil; oleuropein aglycone supports mitophagy, SIRT1, and AMPK activation
Rosemary diterpene linked to antioxidant and anti-inflammatory signaling in preclinical models.
Rosemary diterpene with anti-inflammatory and anti-cancer mechanistic evidence from preclinical literature.
Thymol isomer in thyme and related Lamiaceae herbs; chemotype-dependent.
Phenolic monoterpene that defines thyme aroma; concentration varies by chemotype and drying.
Key aromatic compound in cinnamon; supports glycemic control and insulin sensitivity