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Oleacein

Overview​

Oleacein is a secoiridoid polyphenol found in extra-virgin olive oil, particularly in early harvest oils. It acts as a potent antioxidant and activates the NRF2 pathway, which regulates cellular antioxidant defenses. Oleacein is one of the key bioactive compounds that contribute to the brain health benefits of extra-virgin olive oil through antioxidant mechanisms.

Recipes​

5 recipes containing this substance

Ginger Yogurt and Blueberries

An Anti-inflammatory polyphenol-rich breakfast bowl with high fibre. Start the day with anti-inflammatory gingerols and omega 3 nuts, blueberry polyphenols, a fibre from steel rolled oats. Great to set up dopamine for focus and attention.

Mitochondrial Power Bowl

A nitrate-rich, polyphenol-dense bowl supporting mitochondrial function, ATP generation, and metabolic resilience

Salmon Bowl-pistachio-cacao-nibs

A functional ECS-supportive bowl combining salmon, avocado, pistachios, cacao nibs, and early harvest olive oil to help preserve anandamide tone, improve membrane lipid composition, and support gut–brain signaling.

Turkey Wing Stew

A collagen-rich, glycine-heavy slow-cooked stew made from affordable turkey wings — supporting gut, joint, sleep, and brain health.

Foods​

2 foods containing this substance

Olive Oil (Early Harvest)

Premium extra virgin olive oil with enhanced CoQ10, oleuropein, and polyphenol content from early harvest timing

Biological Mechanisms and Implications​

Biological TargetTherapeutic AreasMechanism of Action
Oxidative StressAntioxidant properties; activates NRF2 pathway; supports antioxidant defenses and neuroprotection

References​

  • Oleacein is a secoiridoid polyphenol in extra-virgin olive oil with antioxidant properties and NRF2 activation
  • Found in higher concentrations in early harvest extra-virgin olive oil
  • Contributes to the brain health benefits of olive oil through antioxidant and neuroprotective mechanisms