BRS2-FM1-PM1 - Folate/B12-Dependent Homocysteine Remethylation
1. Definition
Conversion of homocysteine back to methionine through folate- and B12-dependent remethylation.
Within BRS2, this PM specifically captures the folate-, B12-, and B2-dependent regeneration of methionine from homocysteine, rather than downstream methyl donation itself [1][2].
2. Target Functional Outcome / Phenome
These mappings are translational relationships, not single-mechanism outcome claims. Phenomes are emergent functional patterns supported by multiple interacting PMs across the BRAIN Framework.
No direct functional outcome relationship currently mapped.
3. Intervention Breakdown
Food-State Dominant
4. Functional Role
↓ homocysteine; ↑ methionine regeneration
5. Mechanistic Basis
Summary
Conversion of homocysteine back to methionine through folate- and B12-dependent remethylation.
Folate/B12-Dependent Homocysteine Remethylation — mechanistic detail
(Folate/B12-Dependent Homocysteine Remethylation)
Conversion of homocysteine back to methionine through folate- and B12-dependent remethylation. Primary remethylation route highlighted in manuscript section 3.2
6. Connected BRS2 Mechanisms
6.1 Overarching Functional Mechanism
6.2 Connected Primary Mechanisms
- BRS2-FM1-PM2 - Betaine/BHMT Remethylation
- BRS2-FM1-PM3 - SAMe Synthesis
- BRS2-FM1-PM4 - Methionine Cycle Flux
7. Connected Mechanisms
- None listed
8. Dietary Levers
8.1 Direct Dietary Levers
- B12 ← shellfish, dairy, eggs
- Folate ← leafy greens, legumes
8.2 Cofactors and Supporting Inputs
- B2
8.3 KCs (Key Constraints)
9. Lifestyle Levers
Lifestyle
- Consistent daily meal timing may support one-carbon and methyl-donor availability across the day.
- Sleep and stress context may indirectly affect methylation demand; lifestyle factors are secondary to dietary substrate supply for this PM.
10. Scoreable Inputs & Modulation Signals
Scoreable Input Categories
| Input Category | Example Inputs | PM relevance |
|---|---|---|
| Functional Property Potentials | methyl_donor_pattern; sulfur_amino_acid_context; choline_rich_food_matrix | May support folate/b12-dependent homocysteine remethylation. |
| Realised Functional States | consistent_daily_methyl_donor_coverage | May reflect meal-level pathway support. |
| Preparation Transformations | minimally_processed; whole_food_matrix | May preserve nutrient density for pathway support. |