Phenome Registry

Phenomes are functional patterns that sit above biological mechanisms and below condition profiles. They describe what a person may experience functionally, such as energy stability, motivation, emotional regulation, or recovery capacity.

Mechanism-to-phenome links are translational relationships. They do not imply that a single mechanism causes or treats a complex condition.

Registry overview

ID	Phenome	Description	Connected Mechanisms
PH001	Focus / Attention Stability	Capacity to sustain, shift, and regulate attention across changing cognitive demands.	BRS-X(Hormones-PM1) — Oestrogen Signalling Stabilityindirect · low-medium
PH002	Motivation / Drive	Capacity to initiate effort, pursue goals, and maintain goal-directed behaviour.	BRS-X(ECS-PM1) — NAPE → NAE Biosynthesis Capacitysupports · low-medium BRS-X(ECS-PM4) — Endocannabinoid–Dopamine Neuromodulationsupports · medium BRS-X(Hormones-PM5) — Testosterone Signalling Stabilitysupports · medium BRS-X(Hormones-PM6) — Androgen-Microbiome Regulationindirect · low-medium
PH003	Emotional Regulation	Capacity to modulate emotional responses and maintain affective stability.	BRS-X(ECS-PM1) — NAPE → NAE Biosynthesis Capacitymodulates · low-medium BRS-X(ECS-PM2) — Omega-3-Derived Endocannabinoidome Signallingmodulates · low BRS-X(ECS-PM3) — FAAH-Mediated Endocannabinoid Preservationmodulates · low-medium BRS-X(ECS-PM5) — Endocannabinoid Stress-Buffering Capacitymodulates · low-medium BRS-X(Hormones-PM1) — Oestrogen Signalling Stabilitymodulates · medium BRS-X(Hormones-PM2) — Estrobolome Regulationmodulates · medium BRS-X(Hormones-PM3) — Progesterone-Supportive Microbial Metabolismmodulates · low-medium BRS-X(Hormones-PM4) — Metabolic-Reproductive Hormone Integrationindirect · low-medium BRS-X(Hormones-PM5) — Testosterone Signalling Stabilitymodulates · low-medium BRS-X(Hormones-PM6) — Androgen-Microbiome Regulationindirect · low
PH004	Cognitive Energy Stability	Capacity to maintain mental energy and avoid cognitive energy crashes across the day.	BRS-X(Hormones-PM4) — Metabolic-Reproductive Hormone Integrationmodulates · medium BRS-X(Hormones-PM5) — Testosterone Signalling Stabilitymodulates · low-medium BRS-X(Hormones-PM6) — Androgen-Microbiome Regulationindirect · low BRS4-FM1-PM2 — NAD⁺ Metabolismmodulates · low-medium
PH005	Recovery Capacity	Capacity to restore function after cognitive, emotional, metabolic, or physical load.	BRS-X(ECS-PM5) — Endocannabinoid Stress-Buffering Capacitymodulates · low-medium BRS4-FM1-PM2 — NAD⁺ Metabolismmodulates · low-medium BRS4-FM2-PM4 — ROS Production and Controlindirect · low BRS4-FM2-PM5 — Mitochondrial Protection (Redox Integrity)modulates · low-medium BRS4-FM3-PM8 — Metabolic Fuel Switchingindirect · low BRS4-FM4-PM9 — Mitochondrial Biogenesissupports · low-medium
PH006	Stress Resilience	Capacity to buffer, adapt to, and recover from stress exposure.	BRS-X(ECS-PM1) — NAPE → NAE Biosynthesis Capacitymodulates · low-medium BRS-X(ECS-PM2) — Omega-3-Derived Endocannabinoidome Signallingmodulates · low-medium BRS-X(ECS-PM3) — FAAH-Mediated Endocannabinoid Preservationmodulates · low-medium BRS-X(ECS-PM5) — Endocannabinoid Stress-Buffering Capacitysupports · medium
PH007	Metabolic Resilience	Capacity to maintain function under changing metabolic, energetic, or physiological demand.	BRS4-FM2-PM4 — ROS Production and Controlmodulates · low-medium BRS4-FM2-PM5 — Mitochondrial Protection (Redox Integrity)supports · low-medium BRS4-FM3-PM6 — Carnitine-Mediated Fat Transportsupports · low-medium BRS4-FM3-PM7 — Ketone Utilisation Capacitysupports · low BRS4-FM3-PM8 — Metabolic Fuel Switchingsupports · low-medium BRS4-FM4-PM9 — Mitochondrial Biogenesissupports · low-medium
PH008	Sleep / Calming Tone	Capacity to downshift arousal and support sleep-compatible physiological regulation.	BRS-X(Hormones-PM3) — Progesterone-Supportive Microbial Metabolismindirect · low
PH009	Reward Regulation	Capacity to regulate reward sensitivity, reinforcement learning, and reward-seeking behaviour.	BRS-X(ECS-PM4) — Endocannabinoid–Dopamine Neuromodulationmodulates · low-medium
PH010	Behavioural Activation	Capacity to translate motivation into action, task initiation, and sustained behavioural engagement.	BRS-X(ECS-PM4) — Endocannabinoid–Dopamine Neuromodulationmodulates · low-medium
PH011	Cognitive Clarity	Capacity to maintain clear, organised mental processing without excessive fog or confusion.	BRS-X(ECS-PM2) — Omega-3-Derived Endocannabinoidome Signallingmodulates · low-medium BRS-X(Hormones-PM1) — Oestrogen Signalling Stabilitymodulates · medium BRS-X(Hormones-PM2) — Estrobolome Regulationindirect · low-medium
PH012	Energy Stability Under Variable Conditions	Capacity to maintain energy output when nutritional, physiological, or environmental conditions change.	BRS4-FM3-PM8 — Metabolic Fuel Switchingsupports · low-medium
PH013	Energy Stability Under Variable Fuel Conditions	Capacity to maintain ATP-linked energy supply when available fuel substrates or macronutrient context change.	BRS4-FM3-PM6 — Carnitine-Mediated Fat Transportmodulates · low-medium BRS4-FM3-PM7 — Ketone Utilisation Capacitymodulates · low-medium
PH014	Hormonal Volatility	Stability of hormone-linked signalling patterns that influence mood, cognition, and physiological regulation.	BRS-X(Hormones-PM2) — Estrobolome Regulationmodulates · medium BRS-X(Hormones-PM4) — Metabolic-Reproductive Hormone Integrationmodulates · medium
PH015	Stress Reactivity	Intensity and pattern of physiological and affective responses to stressors.	BRS-X(Hormones-PM3) — Progesterone-Supportive Microbial Metabolismindirect · low-medium

Phenome details

PH001 — Focus / Attention Stability

Capacity to sustain, shift, and regulate attention across changing cognitive demands.

How steadily a person can hold, shift, and return attention when tasks or distractions change.

Connected mechanisms

• BRS-X(Hormones-PM1) — Oestrogen Signalling Stability (indirect · low-medium)

PH002 — Motivation / Drive

Capacity to initiate effort, pursue goals, and maintain goal-directed behaviour.

How readily a person starts effort, pursues goals, and stays engaged with what matters to them.

Connected mechanisms

BRS-X(ECS)

• BRS-X(ECS-PM1) — NAPE → NAE Biosynthesis Capacity (supports · low-medium)
• BRS-X(ECS-PM4) — Endocannabinoid–Dopamine Neuromodulation (supports · medium)

BRS-X(Hormones)

• BRS-X(Hormones-PM5) — Testosterone Signalling Stability (supports · medium)
• BRS-X(Hormones-PM6) — Androgen-Microbiome Regulation (indirect · low-medium)

PH003 — Emotional Regulation

Capacity to modulate emotional responses and maintain affective stability.

How well emotional responses can be modulated so mood and reactivity stay within a workable range.

Connected mechanisms

BRS-X(ECS)

• BRS-X(ECS-PM1) — NAPE → NAE Biosynthesis Capacity (modulates · low-medium)
• BRS-X(ECS-PM2) — Omega-3-Derived Endocannabinoidome Signalling (modulates · low)
• BRS-X(ECS-PM3) — FAAH-Mediated Endocannabinoid Preservation (modulates · low-medium)
• BRS-X(ECS-PM5) — Endocannabinoid Stress-Buffering Capacity (modulates · low-medium)

BRS-X(Hormones)

• BRS-X(Hormones-PM1) — Oestrogen Signalling Stability (modulates · medium)
• BRS-X(Hormones-PM2) — Estrobolome Regulation (modulates · medium)
• BRS-X(Hormones-PM3) — Progesterone-Supportive Microbial Metabolism (modulates · low-medium)
• BRS-X(Hormones-PM4) — Metabolic-Reproductive Hormone Integration (indirect · low-medium)
• BRS-X(Hormones-PM5) — Testosterone Signalling Stability (modulates · low-medium)
• BRS-X(Hormones-PM6) — Androgen-Microbiome Regulation (indirect · low)

PH004 — Cognitive Energy Stability

Capacity to maintain mental energy and avoid cognitive energy crashes across the day.

How evenly mental energy holds up through the day without sharp crashes or fog.

Connected mechanisms

BRS-X(Hormones)

• BRS-X(Hormones-PM4) — Metabolic-Reproductive Hormone Integration (modulates · medium)
• BRS-X(Hormones-PM5) — Testosterone Signalling Stability (modulates · low-medium)
• BRS-X(Hormones-PM6) — Androgen-Microbiome Regulation (indirect · low)

• BRS4-FM1-PM2 — NAD⁺ Metabolism (modulates · low-medium)

PH005 — Recovery Capacity

Capacity to restore function after cognitive, emotional, metabolic, or physical load.

How effectively function returns after sustained cognitive, emotional, metabolic, or physical demand.

Connected mechanisms

• BRS-X(ECS-PM5) — Endocannabinoid Stress-Buffering Capacity (modulates · low-medium)

BRS4

• BRS4-FM1-PM2 — NAD⁺ Metabolism (modulates · low-medium)
• BRS4-FM2-PM4 — ROS Production and Control (indirect · low)
• BRS4-FM2-PM5 — Mitochondrial Protection (Redox Integrity) (modulates · low-medium)
• BRS4-FM3-PM8 — Metabolic Fuel Switching (indirect · low)
• BRS4-FM4-PM9 — Mitochondrial Biogenesis (supports · low-medium)

PH006 — Stress Resilience

Capacity to buffer, adapt to, and recover from stress exposure.

How well the system buffers stress, adapts under pressure, and returns toward baseline afterward.

Connected mechanisms

BRS-X(ECS)

• BRS-X(ECS-PM1) — NAPE → NAE Biosynthesis Capacity (modulates · low-medium)
• BRS-X(ECS-PM2) — Omega-3-Derived Endocannabinoidome Signalling (modulates · low-medium)
• BRS-X(ECS-PM3) — FAAH-Mediated Endocannabinoid Preservation (modulates · low-medium)
• BRS-X(ECS-PM5) — Endocannabinoid Stress-Buffering Capacity (supports · medium)

PH007 — Metabolic Resilience

Capacity to maintain function under changing metabolic, energetic, or physiological demand.

How well the body and brain maintain stable function when energy demand, fuel availability, or metabolic conditions change.

Connected mechanisms

BRS4

• BRS4-FM2-PM4 — ROS Production and Control (modulates · low-medium)
• BRS4-FM2-PM5 — Mitochondrial Protection (Redox Integrity) (supports · low-medium)
• BRS4-FM3-PM6 — Carnitine-Mediated Fat Transport (supports · low-medium)
• BRS4-FM3-PM7 — Ketone Utilisation Capacity (supports · low)
• BRS4-FM3-PM8 — Metabolic Fuel Switching (supports · low-medium)
• BRS4-FM4-PM9 — Mitochondrial Biogenesis (supports · low-medium)

PH008 — Sleep / Calming Tone

Capacity to downshift arousal and support sleep-compatible physiological regulation.

How readily arousal can downshift toward calmer, sleep-compatible physiological states.

Connected mechanisms

• BRS-X(Hormones-PM3) — Progesterone-Supportive Microbial Metabolism (indirect · low)

PH009 — Reward Regulation

Capacity to regulate reward sensitivity, reinforcement learning, and reward-seeking behaviour.

How reward sensitivity, reinforcement learning, and reward-seeking behaviour are regulated over time.

Connected mechanisms

• BRS-X(ECS-PM4) — Endocannabinoid–Dopamine Neuromodulation (modulates · low-medium)

PH010 — Behavioural Activation

Capacity to translate motivation into action, task initiation, and sustained behavioural engagement.

How effectively motivation converts into starting tasks and sustaining behavioural engagement.

Connected mechanisms

• BRS-X(ECS-PM4) — Endocannabinoid–Dopamine Neuromodulation (modulates · low-medium)

PH011 — Cognitive Clarity

Capacity to maintain clear, organised mental processing without excessive fog or confusion.

How clear and organised thinking feels — distinct from attention stability or raw mental energy.

Connected mechanisms

• BRS-X(ECS-PM2) — Omega-3-Derived Endocannabinoidome Signalling (modulates · low-medium)

BRS-X(Hormones)

• BRS-X(Hormones-PM1) — Oestrogen Signalling Stability (modulates · medium)
• BRS-X(Hormones-PM2) — Estrobolome Regulation (indirect · low-medium)

PH012 — Energy Stability Under Variable Conditions

Capacity to maintain energy output when nutritional, physiological, or environmental conditions change.

How steadily energy production holds when conditions around nutrition, physiology, or demand shift.

Connected mechanisms

• BRS4-FM3-PM8 — Metabolic Fuel Switching (supports · low-medium)

PH013 — Energy Stability Under Variable Fuel Conditions

Capacity to maintain ATP-linked energy supply when available fuel substrates or macronutrient context change.

How well energy supply holds when glucose, fat, ketone, or mixed fuel availability changes.

Connected mechanisms

BRS4

• BRS4-FM3-PM6 — Carnitine-Mediated Fat Transport (modulates · low-medium)
• BRS4-FM3-PM7 — Ketone Utilisation Capacity (modulates · low-medium)

PH014 — Hormonal Volatility

Stability of hormone-linked signalling patterns that influence mood, cognition, and physiological regulation.

How stable hormone-linked signalling feels over time — as distinct from a single hormone mechanism.

Connected mechanisms

BRS-X(Hormones)

• BRS-X(Hormones-PM2) — Estrobolome Regulation (modulates · medium)
• BRS-X(Hormones-PM4) — Metabolic-Reproductive Hormone Integration (modulates · medium)

PH015 — Stress Reactivity

Intensity and pattern of physiological and affective responses to stressors.

How strongly and quickly the system reacts to stress — distinct from longer-term stress resilience.

Connected mechanisms

• BRS-X(Hormones-PM3) — Progesterone-Supportive Microbial Metabolism (indirect · low-medium)

Registry review flags

The following phenome pairs are flagged for manual review (not merged automatically).

• RF001 (near_duplicate): Near-duplicate energy/fuel stability labels — consider merging under one canonical phenome after manual review. — Energy Stability Under Variable Conditions / Energy Stability Under Variable Fuel Conditions
• RF002 (related_distinct): Stress Resilience (adaptive capacity) vs Stress Reactivity (response intensity) — related but not identical; do not merge automatically. — Stress Resilience / Stress Reactivity
• RF003 (related_distinct): Motivation/Drive vs Behavioural Activation — related; remain separate unless manually merged. — Motivation / Drive / Behavioural Activation