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PH014 — Hormonal Volatility

Stability of hormone-linked signalling patterns that influence mood, cognition, and physiological regulation.

How stable hormone-linked signalling feels over time — as distinct from a single hormone mechanism.

Therapeutic areas: TA001 ★TA002TA003TA004

Provenance: Core Version 1 registry phenome for hormone-linked signalling stability affecting mood and cognition. Cross-referenced to gut–estrobolome and insulin–estrogen biology from BRS-X Hormones workstream. (origin: BRAIN)

Related phenomes: PH003 — Emotional Regulation, PH004 — Cognitive Energy Stability

External framework cross-references

RDoC domains

  • Arousal and Regulatory Systems — endocrine / hormonal regulation

DSM / ICD context

  • Premenstrual dysphoric disorder
  • Perimenopause — mood and cognitive volatility

Foundational Evidence

Evidence Confidence: Low–Medium

Registry-level score for this phenome's foundational evidence stack — not Biology → Phenome Confidence on individual mechanism pages.

Estrobolome and sex-hormone signalling reviews are mechanistically strong; human dietary hormone-stability trials are not represented on the foundational stack.

Registry-level foundational evidence for this phenome. Mechanism pages link to phenome IDs and carry relationship-specific evidence — not duplicated here.

Construct landmark papers

  • Hu et al. (2023) — Gut microbial beta-glucuronidase and estrogen recirculation — hormonal volatility biology.
  • Li et al. (2023) — Mitochondrial and neuroendocrine function intersecting mood and cognitive regulation.

Biology → phenome landmark papers

  • Depaoli et al. (2021) — Estrogen–insulin resistance coupling and neuropsychiatric endocrine volatility.
  • Ervin et al. (2019) — Estrobolome beta-glucuronidase activity and estrogen signalling stability.

Nutrition → biology landmark papers

  • Sui et al. (2021) — Dietary modulation of gut beta-glucuronidase and estrogen reactivation.
  • D'Afflitto et al. (2022) — Sex hormones, gut microbiota, and dietary signalling intersecting endocrine stability.

Connected mechanisms

BRS-X(Hormones)