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← Phenome Registry

PH011 — Cognitive Clarity

Capacity to maintain clear, organised mental processing without excessive fog or confusion.

How clear and organised thinking feels — distinct from attention stability or raw mental energy.

Therapeutic areas: TA001 ★TA002TA003TA004TA005TA006TA007

Provenance: Core Version 1 registry phenome for mental processing clarity (distinct from Focus/Attention Stability PH001 and Cognitive Energy PH004). Enriched with cross-system oxidative and micronutrient biology. (origin: BRAIN)

Related phenomes: PH001 — Focus / Attention Stability, PH004 — Cognitive Energy Stability

External framework cross-references

RDoC domains

  • Cognitive Systems — cognitive control / processing efficiency

DSM / ICD context

  • Attention-deficit/hyperactivity disorder — cognitive symptoms
  • Mild cognitive impairment

Foundational Evidence

Evidence Confidence: Low–Medium

Registry-level score for this phenome's foundational evidence stack — not Biology → Phenome Confidence on individual mechanism pages.

Oxidative-stress and omega-3 cognition reviews support biology→phenome; homocysteine and gut–estrogen links are mechanistic — clarity outcomes not isolated as primary endpoints on the stack.

Registry-level foundational evidence for this phenome. Mechanism pages link to phenome IDs and carry relationship-specific evidence — not duplicated here.

Construct landmark papers

  • Derbyshire & Maes (2023) — Neuroinflammation and oxidative stress in ADHD — cognitive symptom construct context.
  • Liu et al. (2014) — Homocysteine and cognitive function — clarity/processing efficiency framing.

Biology → phenome landmark papers

Nutrition → biology landmark papers

  • Oulhaj et al. (2016) — Omega-3 supplementation and cognitive performance — human nutrition→cognition support.
  • Watson et al. (2019) — Gut–brain signalling and cognitive health — microbiome nutrition context.

Connected mechanisms

BRS-X(Hormones)

BRS1

BRS2

BRS3