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← Phenome Registry

PH001 — Focus / Attention Stability

Capacity to sustain, shift, and regulate attention across changing cognitive demands.

How steadily a person can hold, shift, and return attention when tasks or distractions change.

Therapeutic areas: TA001 ★TA002TA004TA005TA006TA007

Provenance: Core Version 1 ADHD registry phenome (pre-v3). Benchmarked against RDoC Cognitive Systems (attention, cognitive control) and distinguished from Cognitive Clarity (PH011) as sustained/shifted attention versus processing clarity. (origin: BRAIN)

Related phenomes: PH002 — Motivation / Drive, PH011 — Cognitive Clarity

External framework cross-references

RDoC domains

  • Cognitive Systems — attention
  • Cognitive Systems — cognitive control

DSM / ICD context

  • Attention-deficit/hyperactivity disorder

Foundational Evidence

Evidence Confidence: Low–Medium

Registry-level score for this phenome's foundational evidence stack — not Biology → Phenome Confidence on individual mechanism pages.

ADHD-focused construct and precursor-transport biology are well represented; human dietary attention-outcome evidence on the registry stack is indirect (omega-3 cognition trials) — not dietary ADHD treatment efficacy.

Registry-level foundational evidence for this phenome. Mechanism pages link to phenome IDs and carry relationship-specific evidence — not duplicated here.

Construct landmark papers

  • Millichap & Yee (2012) — Reviews diet and nutritional factors in ADHD — foundational construct framing for attention phenotypes.
  • Aquili (2020) — Reviews catecholaminergic neurotransmission and attentional function relevant to ADHD biology.

Biology → phenome landmark papers

  • Fernstrom (2013) — Large neutral amino acid transport and precursor availability intersect monoaminergic attention pathways.
  • Derbyshire & Maes (2023) — Links oxidative stress and neuroinflammation biology to ADHD symptom domains including attention.

Nutrition → biology landmark papers

  • Wang et al. (2019) — Dietary patterns and amino-acid context modulate neurotransmitter precursor biology upstream of attention.
  • Oulhaj et al. (2016) — Omega-3 supplementation associated with cognitive performance improvements in ageing — adjacent human nutrition→cognition support.

Connected mechanisms

BRS1

BRS2

BRS3