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PH004 — Cognitive Energy Stability

Capacity to maintain mental energy and avoid cognitive energy crashes across the day.

How evenly mental energy holds up through the day without sharp crashes or fog.

Therapeutic areas: TA001 ★TA003TA005TA006TA007

Provenance: Core Version 1 registry phenome for mental energy stability across the day. Distinguished from Energy Stability Under Variable Conditions (PH012) and fuel-substrate phenome (PH013) as cognitive energy tone rather than metabolic supply mechanics. (origin: BRAIN)

Related phenomes: PH011 — Cognitive Clarity, PH012 — Energy Stability Under Variable Conditions, PH013 — Energy Stability Under Variable Fuel Conditions

External framework cross-references

RDoC domains

  • Arousal and Regulatory Systems — fatigue / energy regulation
  • Cognitive Systems — cognitive effort

DSM / ICD context

  • Major depressive disorder — fatigue
  • Long COVID — cognitive fatigue

Foundational Evidence

Evidence Confidence: Low–Medium

Registry-level score for this phenome's foundational evidence stack — not Biology → Phenome Confidence on individual mechanism pages.

Mitochondrial and metabolic-flexibility reviews anchor the construct; micronutrient and sex-hormone links are mechanistic — limited direct cognitive-fatigue outcome demonstration on the registry stack.

Registry-level foundational evidence for this phenome. Mechanism pages link to phenome IDs and carry relationship-specific evidence — not duplicated here.

Construct landmark papers

  • Li et al. (2023) — Mitochondrial function and brain energy metabolism in neuropsychiatric contexts.
  • Goodpaster & Sparks (2017) — Metabolic flexibility review — substrate switching and energetic resilience framing.

Biology → phenome landmark papers

  • Depaoli et al. (2021) — Estrogen–insulin resistance biology intersects brain energy and mood regulation.
  • Pirinen et al. (2020) — NAD⁺/mitochondrial biology and human energy metabolism — bioenergetic phenome context.

Nutrition → biology landmark papers

  • Tardy et al. (2020) — B-vitamin supplementation and fatigue/energy outcomes — micronutrient→bioenergetic biology.
  • Pirinen et al. (2020) — Niacin/NAD precursor intervention modulates mitochondrial energetic capacity in humans.

Connected mechanisms

BRS-X(Hormones)