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← Phenome Registry

PH006 — Stress Resilience

Capacity to buffer, adapt to, and recover from stress exposure.

How well the system buffers stress, adapts under pressure, and returns toward baseline afterward.

Therapeutic areas: TA001 ★TA002TA003TA006

Provenance: Core Version 1 registry phenome for adaptive stress buffering. Benchmarked against RDoC Negative Valence and Arousal systems; distinct from Stress Reactivity (PH015) per RF002. (origin: BRAIN)

Related phenomes: PH015 — Stress Reactivity

External framework cross-references

RDoC domains

  • Negative Valence Systems — sustained threat / stress adaptation
  • Arousal and Regulatory Systems — stress regulation

DSM / ICD context

  • Generalised anxiety disorder
  • Post-traumatic stress disorder — resilience contexts

Foundational Evidence

Evidence Confidence: Low–Medium

Registry-level score for this phenome's foundational evidence stack — not Biology → Phenome Confidence on individual mechanism pages.

Endocannabinoid and stress-adaptation reviews are strong; human dietary stress-resilience outcomes are indirect (omega-3 anxiety, oatmeal preclinical adjunct).

Registry-level foundational evidence for this phenome. Mechanism pages link to phenome IDs and carry relationship-specific evidence — not duplicated here.

Construct landmark papers

  • Garani et al. (2021) — Endocannabinoid system in stress modulation and behavioural adaptation.
  • Oades et al. (2010) — Monoaminergic systems in stress-related motivation and affect — ADHD-adjacent framing.

Biology → phenome landmark papers

  • Watson et al. (2019) — Emerging gut–brain signalling and stress-related neuroimmune biology.
  • Mamiya et al. (2021) — Precision psychiatry framing for excitation–inhibition balance in stress-related phenotypes.

Nutrition → biology landmark papers

Connected mechanisms

BRS-X(ECS)

BRS3