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BRS-X(ECS) — Endocannabinoid SystemBRS-X(Hormones) — Hormone Signalling & Regulation

BRS-X - Cross-System Regulation​

Overview​

Biological Regulatory Systems (BRSs) describe the primary domains of biological regulation targeted by the BRAIN Framework. However, some biological systems operate across multiple BRSs simultaneously and cannot be accurately represented within a single domain.

BRS-X systems capture these cross-system regulatory networks. They function as higher-order signalling architectures that influence multiple BRSs concurrently and provide important integration layers within the wider framework.

BRS-X Systems​

BRS-X(ECS) — Endocannabinoid System​

Cross-system signalling network involved in neurotransmission, inflammation, metabolism, mitochondrial regulation, gut–brain communication, appetite regulation, stress adaptation, and neuroplasticity.

BRS-X(Hormones) — Hormone Signalling & Regulation​

Cross-system endocrine signalling network governing hormone production, hormone-responsive regulation, microbial hormone metabolism, hormone recycling, and neuroendocrine communication across multiple biological systems.

Scope includes estrogen, progesterone, and testosterone signalling; hormone–microbiome interactions; estrobolome and androbolome biology; and hormonal adaptation across life stages.