PH005 — Recovery Capacity
Capacity to restore function after cognitive, emotional, metabolic, or physical load.
How effectively function returns after sustained cognitive, emotional, metabolic, or physical demand.
Therapeutic areas: TA001 ★TA005TA006TA007
Provenance: Core Version 1 registry phenome for post-load functional restoration. Related to Stress Resilience (PH006) and Metabolic Resilience (PH007) but targets recovery trajectory rather than buffering or substrate flexibility alone. (origin: BRAIN)
Related phenomes: PH006 — Stress Resilience, PH007 — Metabolic Resilience
External framework cross-references
RDoC domains
- Arousal and Regulatory Systems — recovery / homeostatic regulation
DSM / ICD context
- Long COVID — post-exertional recovery
- Chronic fatigue contexts
Foundational Evidence
Evidence Confidence: Low–Medium
Registry-level score for this phenome's foundational evidence stack — not Biology → Phenome Confidence on individual mechanism pages.
Recovery biology spans redox, NAD⁺, and metabolic-flexibility reviews; human nutrition evidence is supportive but not recovery-phenome-specific RCTs.
Registry-level foundational evidence for this phenome. Mechanism pages link to phenome IDs and carry relationship-specific evidence — not duplicated here.
Construct landmark papers
- Goodpaster & Sparks (2017) — Metabolic flexibility as capacity to restore and adapt energetic state after demand.
- de Guia et al. (2019) — NAD⁺ biology and cellular resilience — recovery-oriented bioenergetic framing.
Biology → phenome landmark papers
- Verlaet et al. (2019) — Oxidative stress biology in ADHD — load-and-recovery redox context.
- Sekhar et al. (2011) — Glutathione synthesis and redox recovery capacity in humans.
Nutrition → biology landmark papers
- Minich & Brown (2019) — Dietary and supplemental strategies supporting glutathione biology.
- Clerc et al. (2013) — Magnesium and stress-recovery physiology — nutritional modulator of restorative biology.
Connected mechanisms
- BRS-X(ECS-PM5) — Endocannabinoid Stress-Buffering Capacity (modulates · low)
- BRS1-FM4-PM10 — Excitotoxicity Modulation (modulates · low)
BRS2
- BRS2-FM2-PM5 — Transsulfuration Pathway (indirect · low)
- BRS2-FM2-PM6 — Glutathione Synthesis (modulates · low-medium)
BRS4
- BRS4-FM1-PM2 — NAD⁺ Metabolism (modulates · low-medium)
- BRS4-FM2-PM4 — ROS Production and Control (indirect · low)
- BRS4-FM2-PM5 — Mitochondrial Protection (Redox Integrity) (modulates · low-medium)
- BRS4-FM3-PM8 — Metabolic Fuel Switching (indirect · low)
- BRS4-FM4-PM9 — Mitochondrial Biogenesis (supports · low-medium)