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← Phenome Registry

PH003 — Emotional Regulation

Capacity to modulate emotional responses and maintain affective stability.

How well emotional responses can be modulated so mood and reactivity stay within a workable range.

Therapeutic areas: TA001 ★TA002TA003TA004TA006

Provenance: Core Version 1 ADHD registry phenome. Benchmarked against RDoC Negative Valence and Arousal/Regulatory Systems; distinct from Apprehensive Worry (PH016), Stress Reactivity (PH015), and Social Engagement (PH018). (origin: BRAIN)

Related phenomes: PH015 — Stress Reactivity, PH016 — Apprehensive Worry / Perseverative Thought, PH018 — Social Engagement Capacity

External framework cross-references

RDoC domains

  • Negative Valence Systems — sustained affect / affective regulation
  • Arousal and Regulatory Systems — affective regulation

DSM / ICD context

  • Attention-deficit/hyperactivity disorder — emotional dysregulation
  • Major depressive disorder
  • Generalised anxiety disorder

Foundational Evidence

Evidence Confidence: Low–Medium

Registry-level score for this phenome's foundational evidence stack — not Biology → Phenome Confidence on individual mechanism pages.

Construct and inhibitory-balance biology are strong; registry nutrition layer draws on mood/anxiety intervention reviews — not direct emotional-regulation phenome trials.

Registry-level foundational evidence for this phenome. Mechanism pages link to phenome IDs and carry relationship-specific evidence — not duplicated here.

Construct landmark papers

  • Oades et al. (2010) — Reviews dopamine and serotonin roles in motivation, affect, and ADHD-related emotional function.
  • Edden et al. (2012) — GABA deficits in ADHD cohorts — construct validation for excitation–inhibition and affective control.

Biology → phenome landmark papers

  • Fernstrom (2013) — Serotonergic precursor biology intersects affective modulation pathways.
  • Briguglio et al. (2018) — Dietary neurotransmitter biology review spanning mood and anxiety-relevant serotonergic context.

Nutrition → biology landmark papers

  • Kiecolt-Glaser et al. (2011) — Omega-3 lowered anxiety and inflammatory markers in stressed adults — upstream affective biology.
  • Jackson et al. (2021) — Saffron RCT reported mood improvements — adjacent human nutrition→affective biology support.

Connected mechanisms

BRS-X(ECS)

BRS-X(Hormones)

BRS1

BRS3