PH009 — Reward Regulation
Capacity to regulate reward sensitivity, reinforcement learning, and reward-seeking behaviour.
How reward sensitivity, reinforcement learning, and reward-seeking behaviour are regulated over time.
Therapeutic areas: TA001 ★TA002TA003TA007
Provenance: Core Version 1 registry phenome for reward sensitivity and reinforcement learning. Distinct from Pleasure & Interest Capacity (PH017) and Motivation/Drive (PH002) per RF005. (origin: BRAIN)
Related phenomes: PH002 — Motivation / Drive, PH017 — Pleasure & Interest Capacity
External framework cross-references
RDoC domains
- Positive Valence Systems — reward valuation
- Positive Valence Systems — reward learning
DSM / ICD context
- Attention-deficit/hyperactivity disorder
- Substance use disorder — reward dysregulation contexts
Foundational Evidence
Evidence Confidence: Low
Registry-level score for this phenome's foundational evidence stack — not Biology → Phenome Confidence on individual mechanism pages.
Endocannabinoid reward biology is review-supported but sparse on mechanism pages; registry stack lacks direct human reward-regulation outcome trials.
Registry-level foundational evidence for this phenome. Mechanism pages link to phenome IDs and carry relationship-specific evidence — not duplicated here.
Construct landmark papers
- Covey et al. (2017) — Endocannabinoid modulation of reward processing and reinforcement.
- Gruber et al. (2023) — Insulin–dopamine reward-processing disruption in depression — reward regulation construct.
Biology → phenome landmark papers
- Solinas et al. (2006) — Anandamide and endocannabinoid signalling in reward-related behaviour.
- Oades et al. (2010) — Dopaminergic reward and reinforcement biology in ADHD-related contexts.
Nutrition → biology landmark papers
- Ferguson et al. (2014) — Omega-3 PUFA modulates inflammatory biology intersecting mood/reward pathways.
- Jackson et al. (2021) — Saffron RCT mood outcomes — adjacent human nutrition→reward-affect biology.
Connected mechanisms
- BRS-X(ECS-PM4) — Endocannabinoid–Dopamine Neuromodulation (modulates · low-medium)
- BRS1-FM1-PM4 — Serotonergic Signalling Regulation (modulates · low)