PH015 — Stress Reactivity
Intensity and pattern of physiological and affective responses to stressors.
How strongly and quickly the system reacts to stress — distinct from longer-term stress resilience.
Therapeutic areas: TA001 ★TA002TA004TA006
Provenance: Core Version 1 registry phenome for stress-response intensity. Distinct from Stress Resilience (PH006) per RF002 — reactivity (acute response) versus adaptive buffering. (origin: BRAIN)
Related phenomes: PH006 — Stress Resilience, PH003 — Emotional Regulation
External framework cross-references
RDoC domains
- Negative Valence Systems — acute threat / fear
- Arousal and Regulatory Systems — stress response
DSM / ICD context
- Generalised anxiety disorder
- Attention-deficit/hyperactivity disorder — emotional reactivity
Foundational Evidence
Evidence Confidence: Low–Medium
Registry-level score for this phenome's foundational evidence stack — not Biology → Phenome Confidence on individual mechanism pages.
E/I balance and redox biology are review-supported; magnesium and homocysteine nutrition links are mechanistic — not stress-reactivity disorder intervention trials.
Registry-level foundational evidence for this phenome. Mechanism pages link to phenome IDs and carry relationship-specific evidence — not duplicated here.
Construct landmark papers
- Mamiya et al. (2021) — Excitation–inhibition balance framing for stress-related psychiatric phenotypes.
- Clerc et al. (2013) — Magnesium and stress-axis physiology — construct validation for reactivity biology.
Biology → phenome landmark papers
- Lukovac et al. (2024) — Serum oxidative stress markers in ADHD — load and reactivity biology.
- Gregory et al. (2016) — Homocysteine, B-vitamins, and stress-related neurochemistry.
Nutrition → biology landmark papers
- Kiecolt-Glaser et al. (2011) — Omega-3 reduced stress-related anxiety and inflammation in humans.
- Marsland et al. (2017) — Systemic inflammation and stress-related neural network biology.
Connected mechanisms
- BRS-X(Hormones-PM3) — Progesterone-Supportive Microbial Metabolism (indirect · low)
BRS1
- BRS1-FM4-PM10 — Excitotoxicity Modulation (modulates · low)
- BRS1-FM4-PM7 — GABA–Glutamate Neurotransmission Balance (modulates · low-medium)
- BRS2-FM2-PM5 — Transsulfuration Pathway (modulates · low-medium)