PH008 — Sleep / Calming Tone
Capacity to downshift arousal and support sleep-compatible physiological regulation.
How readily arousal can downshift toward calmer, sleep-compatible physiological states.
Therapeutic areas: TA001 ★TA002TA004TA006
Provenance: Core Version 1 registry phenome for arousal downshift and sleep-compatible regulation. Benchmarked against RDoC Arousal/Regulatory Systems (sleep–wake, circadian). (origin: BRAIN)
Related phenomes: PH003 — Emotional Regulation, PH015 — Stress Reactivity
External framework cross-references
RDoC domains
- Arousal and Regulatory Systems — sleep–wake regulation
- Arousal and Regulatory Systems — circadian rhythms
DSM / ICD context
- Insomnia disorder
- ADHD — sleep disturbance
Foundational Evidence
Evidence Confidence: Low–Medium
Registry-level score for this phenome's foundational evidence stack — not Biology → Phenome Confidence on individual mechanism pages.
GABAergic sleep biochemistry is mechanistically strong (Cataldo); human dietary sleep-outcome evidence on the registry stack is limited — not sleep-disorder treatment efficacy.
Registry-level foundational evidence for this phenome. Mechanism pages link to phenome IDs and carry relationship-specific evidence — not duplicated here.
Construct landmark papers
- Cataldo et al. (2024) — Comprehensive review of PLP-dependent GABA synthesis and sleep-relevant inhibitory neurochemistry.
- Fernstrom (2013) — Precursor biology intersecting serotonergic sleep–wake and calming tone pathways.
Biology → phenome landmark papers
- Cataldo et al. (2024) — Glutamate decarboxylase and GABA synthesis as principal calming neurophysiology.
- D'Afflitto et al. (2022) — Sex-hormone and gut–microbiota signalling intersect sleep and arousal regulation.
Nutrition → biology landmark papers
- Bravo et al. (2011) — Gut–brain GABAergic modulation via microbiota — dietary probiotic context for calming biology.
- Clerc et al. (2013) — Magnesium and neuromuscular/sleep-related physiology — nutritional calming-tone modulator.
Connected mechanisms
- BRS-X(Hormones-PM3) — Progesterone-Supportive Microbial Metabolism (indirect · low)
BRS1
- BRS1-FM1-PM4 — Serotonergic Signalling Regulation (supports · medium)
- BRS1-FM4-PM8 — GABA Synthesis Capacity (modulates · high)