Inflammation & Oxidative Stress
Chronic inflammation and oxidative stress as one interconnected system; modifiable contributors to ADHD and neurocognitive symptom severity
Chronic inflammation and oxidative stress as one interconnected system; modifiable contributors to ADHD and neurocognitive symptom severity
How dietary fibre supports the microbiome, how tolerance develops, and why gradual exposure improves digestive regulation.
How the gut and brain communicate via neural, hormonal, and immune pathways, and why diet influences this bidirectional signalling.
A polyphenol-rich breakfast bowl with high fibre, combining ginger, omega-3 nuts, blueberry polyphenols, and probiotic yogurt.
Whole-wheat linguine with cockles in a silky emulsified sauce; Italian emulsification technique without cream, supporting taurine, B12, and choline intake.
Turmeric- and ginger-spiced lentil dish rich in fibre, folate, and polyphenols
A warming drink combining turmeric (curcumin) with milk/fat for enhanced curcumin absorption
Polyphenolic alkaloid; glycemic control; antimicrobial effects; microbiome modulation
Polysaccharides with immune-modulating properties found in mushrooms and other foods
Complex carbohydrates with immune-modulating and gut microbiome supporting properties
Neuroprotective carotenoid; vitamin A precursor; supports immune regulation and neuronal development
Neuroprotective carotenoid; accumulates in neural tissues and retina; supports cognitive performance
Neuroprotective carotenoid; found in tomatoes; absorption enhanced by cooking and dietary fat
Neuroprotective carotenoid; accumulates in neural tissues and retina; supports cognitive performance
Acetylcholine precursor; methyl donor; phospholipid synthesis for membranes
Anti-inflammatory, antioxidant; bioavailability enhanced with piperine and fats
Polyphenol; antioxidant; gut barrier/LPS modulation; supports microbiome
Polyphenol; antioxidant; mitochondrial support; bioavailability improved with vitamin C
Soy isoflavone; ECS modulation via FAAH inhibition; anti-inflammatory/neuroprotective
Potent antioxidant polyphenol from extra-virgin olive oil; anti-inflammatory
Secoiridoid polyphenol in extra-virgin olive oil; NF-κB inhibition and anti-inflammatory effects
Major secoiridoid polyphenol in olive oil; oleuropein aglycone supports mitophagy, SIRT1, and AMPK activation
Mood and cognition support; sensitive to heat/light; culinary-first use
Most abundant SCFA supporting gut barrier integrity and immune regulation
Key SCFA supporting mitochondrial function, gut barrier integrity, and neuroinflammation reduction
SCFA supporting neuroinflammation reduction, blood-brain barrier protection, and neurotransmitter regulation
Microbial metabolites supporting gut barrier, immune tone, and brain function
Microbiome-derived metabolite from ellagitannins; supports mitochondrial resilience and mitophagy
Essential omega-3 precursor; limited conversion to DHA/EPA
Accounts for ~10–15% of total brain fatty acids, 20–30% of neuronal phospholipids (PE, PS), and >90% of brain omega-3 PUFA; critical for membrane fluidity, synaptic vesicle fusion, neurodevelopment
The "intermediate" between EPA ↔ DHA; important in vascular health, repair, and immune modulation
Potent anti-inflammatory; precursor to E-series resolvins; modulates dopamine and serotonin signalling
(EPA, DHA) Anti-inflammatory, membrane, and neuromodulatory lipids central to BRAIN Diet
Omega-6 PUFA; eicosanoid precursor; balance with omega-3s
Essential omega-6; precursor to arachidonic acid and eicosanoids
Cofactor in redox enzymes; dopamine β-hydroxylase; iron metabolism interplay
Cofactor in neurotransmission and antioxidant enzymes; dopamine modulation
Antioxidant; supports iron absorption; neuronal SVCT2 transport
Dietary strategies targeting inflammation, neurochemical balance, mitochondrial function, and gut-brain axis to support attention, focus, and executive function
Dietary interventions targeting mitochondrial function, oxidative stress, inflammation, and neurochemical balance to slow cognitive decline and support neuroprotection
Nutritional strategies targeting HPA axis regulation, stress response, neurochemical balance, and gut-brain communication to reduce anxiety and support emotional regulation
Nutritional approaches to support mood stability and cognitive function through modulation of neurotransmitter balance, mitochondrial health, and inflammatory pathways
Food-first dietary interventions targeting neurochemical balance, inflammation, gut-brain axis, and metabolic health to support mood regulation and emotional resilience