BRS3(PM6) - Eicosanoid / SPM Balance
1. Definition
Balancing arachidonic-acid-derived inflammatory mediators against EPA/DHA-derived specialized pro-resolving mediators.
This PM captures the shift from inflammatory lipid-mediator dominance toward active resolution capacity, rather than simple suppression of immune activity [1][2][3].
2. Intervention Breakdown
Food-State Dominant
3. Functional Role
↑ pro-resolving mediator bias; ↓ pro-inflammatory eicosanoid dominance
4. Mechanistic Basis
Summary
BRS3(PM6) links marine omega-3 delivery and improved fatty acid balance to greater resolution-oriented lipid signalling within BRS3(FM3) - Inflammation Resolution Capacity [1][2][3].
Eicosanoids, omega-3 balance, and inflammation resolution
(Lipid mediator balance)
Inflammatory tone is shaped partly by the substrate pool available for eicosanoids and specialized pro-resolving mediators, with EPA and DHA supporting resolution pathways that are distinct from simple inflammatory blockade [1].
(Dietary omega-3 patterning)
Repeated oily fish, fish roe, or algal-oil intake helps maintain the substrate context for this PM, while chronically skewed omega-6-dominant and oxidized-fat patterns may oppose it [2][3].
(Resolution placement)
This PM sits centrally within BRS3(FM3) because it governs whether inflammatory lipid signalling transitions toward termination and cleanup rather than prolonged escalation.
5. Underlying Mechanisms and Requirements
5.1 Co-factors
- AA balance
- DHA
- EPA
- selenium
5.2 KCs (Key Constraints)
5.3 Cross-BRS Links
- None listed
6. Dietary Levers
Diet
- EPA/DHA ← oily fish, fish roe, algal oil
- Whole-diet fatty acid balance ← nuts, seeds, minimally processed fat sources
- Lower excess oxidized omega-6 load ← reduced fried and degraded oil exposure
7. Lifestyle Levers
Lifestyle
- Repeated weekly marine-fat exposure matters more than isolated dosing.
- Lower inflammatory load from broader diet and lifestyle context helps preserve resolution capacity once substrate support is present.
8. Scoreable Inputs & Modulation Signals
This PM is scoreable through omega-3 delivery and fatty-acid-balance signals relevant to inflammation resolution.
Scoreable Input Categories
| Input Category | Example Inputs | PM6 Relevance |
|---|---|---|
| Functional Property Potentials | marine_omega3_pattern; fatty_acid_balance; lower_oxidized_oil_load | May support pro-resolving mediator bias. |
| Realised Functional States | oily_fish_pattern; balanced_pufa_context | Reflect practical SPM-supportive states. |
| Substance / Nutrient Signals | EPA; DHA; omega3_to_omega6_balance | Direct lipid-mediator substrate signals for this PM. |
| Preparation Transformations | gentle_fat_cooking; lower_reused_oil_exposure | May help preserve lipid quality relevant to this PM. |