BRS3(KC3) - Essential Fatty Acid Balance
1. Ambition
Maintain balanced essential fatty-acid availability so membrane structure, inflammatory mediator production, and resolution pathways remain supported.
2. Shared Biological Pool
- EPA ← salmon, sardines, mackerel
- DHA ← salmon, trout, algae
- Arachidonic acid ← eggs, poultry, meat
- Omega-3 fatty acids ← oily fish, chia seeds, flax seeds
- Omega-6 fatty acids ← nuts, seeds, eggs
3. Biological Importance
Essential fatty acids serve as membrane components and as precursors for signalling molecules that drive inflammatory activation and resolution. Imbalanced fatty-acid availability can shift inflammatory tone and reduce resolution efficiency.
4. Connected Mechanisms
Functional Mechanisms
Primary Mechanisms
- BRS3-FM1-PM1 - NF-kB Signalling Regulation
- BRS3-FM2-PM3 - Nrf2-ARE Antioxidant Activation
- BRS3-FM2-PM5 - Lipid Peroxidation Control
- BRS3-FM1-PM2 - Gut-Derived Inflammatory Signalling
5. Key References
- Serhan and Petasis (2011) — Resolvins and Protectins in Inflammation Resolution
- Ferguson et al. (2014) — Omega‐3 PUFA Supplementation and the Response to Evoked Endotoxemia in Healthy Volunteers
- McNamara and Carlson (2006) — Potential Implications for the Pathogenesis and Prevention of Psychopathology