BRS2(PM1) - Folate/B12-Dependent Homocysteine Remethylation
1. Definition
Conversion of homocysteine back to methionine through folate- and B12-dependent remethylation.
2. Intervention Breakdown
Food-State Dominant
3. Functional Role
↓ homocysteine; ↑ methionine regeneration
4. Mechanistic Basis
Summary
Conversion of homocysteine back to methionine through folate- and B12-dependent remethylation.
Folate/B12-Dependent Homocysteine Remethylation — mechanistic detail
(Folate/B12-Dependent Homocysteine Remethylation)
Conversion of homocysteine back to methionine through folate- and B12-dependent remethylation. Primary remethylation route highlighted in manuscript section 3.2
Dietary levers include leafy greens; shellfish/dairy/eggs.
5. Underlying Mechanisms and Requirements
5.1 Co-factors
- B2
5.2 KCs (Key Constraints)
5.3 Cross-BRS Links
- None listed
6. Dietary Levers
Diet
- B12 ← shellfish, dairy, eggs
- Folate ← leafy greens, legumes
7. Lifestyle Levers
Lifestyle
- Consistent daily meal timing may support one-carbon and methyl-donor availability across the day.
- Sleep and stress context may indirectly affect methylation demand; lifestyle factors are secondary to dietary substrate supply for this PM.
8. Scoreable Inputs & Modulation Signals
Scoreable Input Categories
| Input Category | Example Inputs | PM relevance |
|---|---|---|
| Functional Property Potentials | methyl_donor_pattern; sulfur_amino_acid_context; choline_rich_food_matrix | May support folate/b12-dependent homocysteine remethylation. |
| Realised Functional States | consistent_daily_methyl_donor_coverage | May reflect meal-level pathway support. |
| Substance / Nutrient Signals | folate; B12 | Direct input signals for this PM. |
| Preparation Transformations | minimally_processed; whole_food_matrix | May preserve nutrient density for pathway support. |