BRS1(FM1) - Catecholaminergic Function (Dopamine + Norepinephrine)
1. Definition
Provision and brain-delivery context of catecholamine precursors and signalling support for dopamine- and norepinephrine-related motivation, attention, arousal, and executive function.
2. Intervention Breakdown
Food-State Leaning
3. Functional Role
↑ precursor availability; ↑ tyrosine/tryptophan support; improved brain-delivery context
4. Mechanistic Basis (Implementation of PMs)
Diet-actionable control of catecholamine precursor supply, LNAA transport bias, and noradrenergic signalling context.
PM1 governs Tyrosine / Tryptophan Precursor Supply. PM2 governs LAT1 Competitive Transport Modulation. PM5 governs Noradrenergic Signalling (Attention & Executive Modulation).
Together, these PMs operationalise BRS1(FM1) as coordinated meal-level control of catecholaminergic and related neurotransmitter signalling.
5. Underlying Mechanisms and Requirements
5.1 Cofactors and Substrates
| PM | Cofactors | KC substrates |
|---|---|---|
| BRS1(PM1) | B6, iron, folate, vitamin C | choline, dietary protein, tryptophan, tyrosine, LNAAs (KC1) |
| BRS1(PM2) | B vitamins indirectly | choline, dietary protein, tryptophan, tyrosine, LNAAs (KC1) |
| BRS1(PM5) | B6, iron, vitamin C | choline, dietary protein, tryptophan, tyrosine, LNAAs (KC1) |
5.2 PMs (Primary Mechanisms)
- BRS1(PM1) - Tyrosine / Tryptophan Precursor Supply
- BRS1(PM2) - LAT1 Competitive Transport Modulation
- BRS1(PM5) - Noradrenergic Signalling (Attention & Executive Modulation)
5.3 KCs (Key Constraints)
5.4 Cross-BRS Links
- None listed
6. Dietary Levers
Diet
- Complementary amino acids ← lentils, grains
- Tryptophan ← chicken, turkey
- Tyrosine ← chicken, turkey
7. Lifestyle Levers
Lifestyle
- Meal timing and protein–carbohydrate composition may modulate neurotransmitter bias where relevant to this FM.
- Sleep regularity and stress-load management may influence downstream neurotransmitter tone (broader modifiers).
8. Scoreable Inputs & Modulation Signals
These inputs are used within the BRAIN Diet ontology to generate evidence-constrained estimates of plausible BRS1 support. They are not direct measures of clinical efficacy.
Scoreable Input Categories
| Input Category | Example Inputs | Functional Relevance |
|---|---|---|
| Functional Property Potentials | complete_protein_context; low_glycaemic_carbohydrate_matrix; phospholipid_dha_context | May support neurotransmitter precursor and membrane-related FM outcomes. |
| Realised Functional States | balanced_lnaa_meal; slow_carbohydrate_pairing; phospholipid_rich_meal | Represent realised meal-level neurotransmitter support patterns. |
| Substance / Nutrient Signals | tyrosine; tryptophan; choline; DHA; B6; iron; magnesium | Substrate and cofactor signals linked to this FM cluster. |
| Preparation Transformations | complementary_protein_pairing; minimally_processed_protein_sources | Modify amino-acid completeness and meal-matrix effects. |