BRS2(PM7) - Phospholipid Methylation
1. Definition
SAMe-dependent methylation of phospholipids affecting membrane composition and receptor function.
2. Intervention Breakdown
Food-State Dominant
3. Functional Role
↑ membrane methylation; ↑ fluidity
4. Mechanistic Basis
Summary
SAMe-dependent methylation of phospholipids affecting membrane composition and receptor function.
Phospholipid Methylation — mechanistic detail
(Phospholipid Methylation)
SAMe-dependent methylation of phospholipids affecting membrane composition and receptor function. Captures the membrane arm emphasized in the manuscript
Dietary levers include eggs/fish roe; oily fish/algal oil.
5. Underlying Mechanisms and Requirements
5.1 Co-factors
- magnesium (indirect — supports SAMe-dependent phospholipid methylation)
5.2 KCs (Key Constraints)
5.3 Cross-BRS Links
- None listed
6. Dietary Levers
Diet
- Choline ← eggs, fish roe
- DHA ← oily fish, algal oil
- EPA ← oily fish, algal oil
- EPA/DHA
- Phosphatidylcholine ← eggs, fish roe
- SAME
7. Lifestyle Levers
Lifestyle
- Consistent daily meal timing may support one-carbon and methyl-donor availability across the day.
- Sleep and stress context may indirectly affect methylation demand; lifestyle factors are secondary to dietary substrate supply for this PM.
8. Scoreable Inputs & Modulation Signals
Scoreable Input Categories
| Input Category | Example Inputs | PM relevance |
|---|---|---|
| Functional Property Potentials | methyl_donor_pattern; sulfur_amino_acid_context; choline_rich_food_matrix | May support phospholipid methylation. |
| Realised Functional States | consistent_daily_methyl_donor_coverage | May reflect meal-level pathway support. |
| Substance / Nutrient Signals | SAMe; choline; DHA/EPA | Direct input signals for this PM. |
| Preparation Transformations | minimally_processed; whole_food_matrix | May preserve nutrient density for pathway support. |