BRS2(PM6) - Glutathione Synthesis
1. Definition
Synthesis of glutathione from cysteine, glycine, and related cofactors downstream of transsulfuration.
2. Intervention Breakdown
Food-State Dominant
3. Functional Role
↑ antioxidant capacity
4. Mechanistic Basis
Summary
Synthesis of glutathione from cysteine, glycine, and related cofactors downstream of transsulfuration.
Glutathione Synthesis — mechanistic detail
(Glutathione Synthesis)
Synthesis of glutathione from cysteine, glycine, and related cofactors downstream of transsulfuration. Integrates BRS2 with redox resilience
Dietary levers include eggs/legumes; brazil nuts/seafood.
5. Underlying Mechanisms and Requirements
5.1 Co-factors
- selenium
- riboflavin
5.2 KCs (Key Constraints)
5.3 Cross-BRS Links
- None listed
6. Dietary Levers
Diet
- Cofactor density ← brazil nuts, seafood
- Cysteine ← eggs, legumes
- Glycine ← eggs, legumes
- Selenium ← brazil nuts, seafood
7. Lifestyle Levers
Lifestyle
- Consistent daily meal timing may support one-carbon and methyl-donor availability across the day.
- Sleep and stress context may indirectly affect methylation demand; lifestyle factors are secondary to dietary substrate supply for this PM.
8. Scoreable Inputs & Modulation Signals
Scoreable Input Categories
| Input Category | Example Inputs | PM relevance |
|---|---|---|
| Functional Property Potentials | methyl_donor_pattern; sulfur_amino_acid_context; choline_rich_food_matrix | May support glutathione synthesis. |
| Realised Functional States | consistent_daily_methyl_donor_coverage | May reflect meal-level pathway support. |
| Substance / Nutrient Signals | glycine; cysteine | Direct input signals for this PM. |
| Preparation Transformations | minimally_processed; whole_food_matrix | May preserve nutrient density for pathway support. |