BRS2(PM2) - Betaine/BHMT Remethylation
1. Definition
Alternative betaine-dependent recycling of homocysteine via the BHMT pathway.
2. Intervention Breakdown
Food-State Dominant
3. Functional Role
↑ alternative Hcy clearance
4. Mechanistic Basis
Summary
Alternative betaine-dependent recycling of homocysteine via the BHMT pathway.
Betaine/BHMT Remethylation — mechanistic detail
(Betaine/BHMT Remethylation)
Alternative betaine-dependent recycling of homocysteine via the BHMT pathway. Complements folate/B12-dependent remethylation as an alternative methyl-donor route for homocysteine clearance.
Dietary levers include beetroot/spinach; eggs/soy lecithin.
5. Underlying Mechanisms and Requirements
5.1 Co-factors
- zinc
5.2 KCs (Key Constraints)
5.3 Cross-BRS Links
- None listed
6. Dietary Levers
Diet
- Betaine ← beetroot, spinach
- Choline ← eggs, soy lecithin
7. Lifestyle Levers
Lifestyle
- Consistent daily meal timing may support one-carbon and methyl-donor availability across the day.
- Sleep and stress context may indirectly affect methylation demand; lifestyle factors are secondary to dietary substrate supply for this PM.
8. Scoreable Inputs & Modulation Signals
Scoreable Input Categories
| Input Category | Example Inputs | PM relevance |
|---|---|---|
| Functional Property Potentials | methyl_donor_pattern; sulfur_amino_acid_context; choline_rich_food_matrix | May support betaine/bhmt remethylation. |
| Realised Functional States | consistent_daily_methyl_donor_coverage | May reflect meal-level pathway support. |
| Substance / Nutrient Signals | betaine; choline | Direct input signals for this PM. |
| Preparation Transformations | minimally_processed; whole_food_matrix | May preserve nutrient density for pathway support. |