BRS2(PM3) - SAMe Synthesis
1. Definition
Production of S-adenosylmethionine from methionine to supply universal methyl donation.
2. Intervention Breakdown
Food-State Dominant
3. Functional Role
↑ methyl donor pool
4. Mechanistic Basis
Summary
Production of S-adenosylmethionine from methionine to supply universal methyl donation.
SAMe Synthesis — mechanistic detail
(SAMe Synthesis)
Production of S-adenosylmethionine from methionine to supply universal methyl donation. Feeds neurotransmitter synthesis and phospholipid methylation
Dietary levers include eggs/meat/fish; magnesium-rich greens/seeds.
5. Underlying Mechanisms and Requirements
5.1 Co-factors
- magnesium
5.2 KCs (Key Constraints)
5.3 Cross-BRS Links
- None listed
6. Dietary Levers
Diet
- Methionine ← eggs, meat, fish
7. Lifestyle Levers
Lifestyle
- Consistent daily meal timing may support one-carbon and methyl-donor availability across the day.
- Sleep and stress context may indirectly affect methylation demand; lifestyle factors are secondary to dietary substrate supply for this PM.
8. Scoreable Inputs & Modulation Signals
Scoreable Input Categories
| Input Category | Example Inputs | PM relevance |
|---|---|---|
| Functional Property Potentials | methyl_donor_pattern; sulfur_amino_acid_context; choline_rich_food_matrix | May support same synthesis. |
| Realised Functional States | consistent_daily_methyl_donor_coverage | May reflect meal-level pathway support. |
| Substance / Nutrient Signals | methionine | Direct input signals for this PM. |
| Preparation Transformations | minimally_processed; whole_food_matrix | May preserve nutrient density for pathway support. |