BRS2(FM3) - Methylation–Membrane Coupling
1. Definition
Integrated regulation of SAMe Synthesis, and Phospholipid Methylation, influencing SAMe-dependent phospholipid methylation to neuronal membrane integrity and signaling.
2. Intervention Breakdown
Food-State Dominant
3. Functional Role
↑ phospholipid methylation; ↑ membrane fluidity; ↑ receptor signaling stability
4. Mechanistic Basis (Implementation of PMs)
Functional coupling of SAMe-dependent phospholipid methylation to neuronal membrane integrity and signaling.
PM3 governs SAMe Synthesis. PM7 governs Phospholipid Methylation.
Together, these PMs operationalise BRS2(FM3) as a coordinated methylation–membrane coupling control point.
5. Underlying Mechanisms and Requirements
5.1 Cofactors and Substrates
| PM | Cofactors | KC substrates |
|---|---|---|
| BRS2(PM3) | magnesium | amino acid support, cysteine, glycine, methionine (KC2) |
| BRS2(PM7) | magnesium (indirect — supports SAMe-dependent phospholipid methylation) | B12, betaine, choline, folate (KC1); amino acid support, cysteine, glycine, methionine (KC2) |
5.2 PMs (Primary Mechanisms)
5.3 KCs (Key Constraints)
5.4 Cross-BRS Links
- None listed
6. Dietary Levers
Diet
- Choline ← eggs, fish roe, liver
- DHA ← oily fish, algal oil
- EPA ← oily fish, algal oil
- Phosphatidylcholine ← eggs, fish roe
7. Lifestyle Levers
Lifestyle
- Regular meal timing and sleep regularity may support SAMe and phospholipid methylation rhythm context.
- Stress and recovery patterns may influence membrane and methylation demand indirectly; dietary substrate remains primary for this FM.
8. Scoreable Inputs & Modulation Signals
These inputs are used within the BRAIN Diet ontology to generate evidence-constrained estimates of plausible BRS2 support. They are not direct measures of clinical efficacy.
Scoreable Input Categories
| Input Category | Example Inputs | Functional Relevance |
|---|---|---|
| Functional Property Potentials | methyl_donor_pattern; transsulfuration_support; choline_phospholipid_context | May support methylation–membrane coupling. |
| Realised Functional States | consistent_methyl_donor_coverage; homocysteine_modulation_context | May reflect integrated FM support at recipe level. |
| Substance / Nutrient Signals | folate; B12; choline; betaine; methionine; omega-3 | Nutrient signals linked to dietary interventions for this FM. |
| Preparation Transformations | minimally_processed; whole_food_matrix | May preserve methyl-donor and cofactor density. |