BRS2(FM2) - Transsulfuration & Redox Coupling
1. Definition
Integrated regulation of Transsulfuration Pathway, and Glutathione Synthesis, influencing homocysteine disposal to cysteine and glutathione production.
2. Intervention Breakdown
Food-State Dominant
3. Functional Role
↑ cysteine generation; ↑ glutathione synthesis; ↓ oxidative load
4. Mechanistic Basis (Implementation of PMs)
Functional coupling of homocysteine disposal to cysteine and glutathione production.
PM5 governs Transsulfuration Pathway. PM6 governs Glutathione Synthesis.
Together, these PMs operationalise BRS2(FM2) as a coordinated transsulfuration and redox control point.
5. Underlying Mechanisms and Requirements
5.1 Cofactors and Substrates
| PM | Cofactors | KC substrates |
|---|---|---|
| BRS2(PM5) | B6 | amino acid support, cysteine, glycine, methionine (KC2) |
| BRS2(PM6) | selenium, riboflavin | amino acid support, cysteine, glycine, methionine (KC2) |
5.2 PMs (Primary Mechanisms)
5.3 KCs (Key Constraints)
5.4 Cross-BRS Links
- None listed
6. Dietary Levers
Diet
- Cysteine ← eggs, poultry, legumes
- Methionine ← eggs, poultry, legumes
- Sulfur + Nrf2 support ← crucifers
- Sulfur compounds ← garlic, onions
7. Lifestyle Levers
Lifestyle
- Regular meal timing may support sulfur amino-acid and glutathione precursor patterns across the day.
- Sleep and stress recovery may influence oxidative and redox demand indirectly; dietary substrate remains primary for this FM.
8. Scoreable Inputs & Modulation Signals
These inputs are used within the BRAIN Diet ontology to generate evidence-constrained estimates of plausible BRS2 support. They are not direct measures of clinical efficacy.
Scoreable Input Categories
| Input Category | Example Inputs | Functional Relevance |
|---|---|---|
| Functional Property Potentials | methyl_donor_pattern; transsulfuration_support; choline_phospholipid_context | May support transsulfuration & redox coupling. |
| Realised Functional States | consistent_methyl_donor_coverage; homocysteine_modulation_context | May reflect integrated FM support at recipe level. |
| Substance / Nutrient Signals | folate; B12; choline; betaine; methionine; omega-3 | Nutrient signals linked to dietary interventions for this FM. |
| Preparation Transformations | minimally_processed; whole_food_matrix | May preserve methyl-donor and cofactor density. |