BRS1(FM5) - Excitatory–Inhibitory Balance (GABA–Glutamate Regulation)
1. Definition
Functional control of excitatory–inhibitory tone through GABA–glutamate balance, supporting neural stability, inhibitory control, and resistance to overstimulation.
2. Intervention Breakdown
Food-State Leaning
3. Functional Role
↑ inhibitory tone support; ↑ GABA synthesis support; ↑ glutamate control; ↑ excitation–inhibition balance
4. Mechanistic Basis (Implementation of PMs)
Integrated control of excitatory–inhibitory tone through GABA–glutamate balance and excitotoxicity modulation.
PM6 governs GABA–Glutamate Neurotransmission Balance. PM7 governs GABA Synthesis Capacity. PM8 governs Glutamate Clearance & Recycling. PM9 governs Excitotoxicity Modulation.
Together, these PMs operationalise BRS1(FM5) as coordinated excitatory–inhibitory balance regulation.
5. Underlying Mechanisms and Requirements
5.1 Cofactors and Substrates
| PM | Cofactors | KC substrates |
|---|---|---|
| BRS1(PM6) | B6, magnesium, zinc | choline, dietary protein, tryptophan, tyrosine, LNAAs (KC1) |
| BRS1(PM7) | B6 (PLP), magnesium | choline, dietary protein, tryptophan, tyrosine, LNAAs (KC1) |
| BRS1(PM8) | Magnesium, antioxidant support indirectly | choline, dietary protein, tryptophan, tyrosine, LNAAs (KC1) |
| BRS1(PM9) | Magnesium, omega-3, antioxidants indirectly | choline, dietary protein, tryptophan, tyrosine, LNAAs (KC1) |
5.2 PMs (Primary Mechanisms)
- BRS1(PM6) - GABA–Glutamate Neurotransmission Balance
- BRS1(PM7) - GABA Synthesis Capacity
- BRS1(PM8) - Glutamate Clearance & Recycling
- BRS1(PM9) - Excitotoxicity Modulation
5.3 KCs (Key Constraints)
5.4 Cross-BRS Links
- BRS6-PM1 — Glycaemic Stability
- BRS3-PM1 — Inflammatory Tone Regulation
- BRS4-PM1 — Mitochondrial Bioenergetic Support
6. Dietary Levers
Diet
- Magnesium ← leafy greens
- Magnesium + B6 ← lentils
- Magnesium + zinc ← pumpkin seeds
- Protein matrix ← yogurt, kefir
- Fermented foods ← yogurt, kefir (GABA-active context)
7. Lifestyle Levers
Lifestyle
- Meal timing and protein–carbohydrate composition may modulate neurotransmitter bias where relevant to this FM.
- Sleep regularity and stress-load management may influence downstream neurotransmitter tone (broader modifiers).
8. Scoreable Inputs & Modulation Signals
These inputs are used within the BRAIN Diet ontology to generate evidence-constrained estimates of plausible BRS1 support. They are not direct measures of clinical efficacy.
Scoreable Input Categories
| Input Category | Example Inputs | Functional Relevance |
|---|---|---|
| Functional Property Potentials | complete_protein_context; low_glycaemic_carbohydrate_matrix; phospholipid_dha_context | May support neurotransmitter precursor and membrane-related FM outcomes. |
| Realised Functional States | balanced_lnaa_meal; slow_carbohydrate_pairing; phospholipid_rich_meal | Represent realised meal-level neurotransmitter support patterns. |
| Substance / Nutrient Signals | tyrosine; tryptophan; choline; DHA; B6; iron; magnesium | Substrate and cofactor signals linked to this FM cluster. |
| Preparation Transformations | complementary_protein_pairing; minimally_processed_protein_sources | Modify amino-acid completeness and meal-matrix effects. |