BRS1(FM4) - Phospholipid-Mediated DHA Delivery & Membrane Integration
1. Definition
Delivery and incorporation of DHA-rich phospholipids into neuronal membranes to support synaptic signalling and membrane function.
2. Intervention Breakdown
Food-State Dominant
3. Functional Role
↑ phospholipid DHA delivery efficiency; ↑ neuronal membrane DHA incorporation; ↑ membrane fluidity context
4. Mechanistic Basis (Implementation of PMs)
DHA-rich phospholipid delivery and neuronal membrane incorporation.
PM4 governs Neuronal Membrane DHA Incorporation.
Together, these PMs operationalise BRS1(FM4) as coordinated phospholipid-mediated DHA delivery.
5. Underlying Mechanisms and Requirements
5.1 Cofactors and Substrates
| PM | Cofactors | KC substrates |
|---|---|---|
| BRS1(PM4) | Choline, phospholipid context | choline, dietary protein, tryptophan, tyrosine, LNAAs (KC1) |
5.2 PMs (Primary Mechanisms)
5.3 KCs (Key Constraints)
5.4 Cross-BRS Links
- None listed
6. Dietary Levers
Diet
- ALA only ← flax, chia
- DHA ← salmon, sardines, mackerel
- DHA + choline ← omega-3 eggs
- Phospholipid DHA ← roe
7. Lifestyle Levers
Lifestyle
- Meal timing and protein–carbohydrate composition may modulate neurotransmitter bias where relevant to this FM.
- Sleep regularity and stress-load management may influence downstream neurotransmitter tone (broader modifiers).
8. Scoreable Inputs & Modulation Signals
These inputs are used within the BRAIN Diet ontology to generate evidence-constrained estimates of plausible BRS1 support. They are not direct measures of clinical efficacy.
Scoreable Input Categories
| Input Category | Example Inputs | Functional Relevance |
|---|---|---|
| Functional Property Potentials | complete_protein_context; low_glycaemic_carbohydrate_matrix; phospholipid_dha_context | May support neurotransmitter precursor and membrane-related FM outcomes. |
| Realised Functional States | balanced_lnaa_meal; slow_carbohydrate_pairing; phospholipid_rich_meal | Represent realised meal-level neurotransmitter support patterns. |
| Substance / Nutrient Signals | tyrosine; tryptophan; choline; DHA; B6; iron; magnesium | Substrate and cofactor signals linked to this FM cluster. |
| Preparation Transformations | complementary_protein_pairing; minimally_processed_protein_sources | Modify amino-acid completeness and meal-matrix effects. |