PH007 — Metabolic Resilience
Capacity to maintain function under changing metabolic, energetic, or physiological demand.
How well the body and brain maintain stable function when energy demand, fuel availability, or metabolic conditions change.
Therapeutic areas: TA001 ★TA005TA006TA007
Provenance: Core Version 1 registry phenome for maintaining function under changing metabolic demand. Overlaps conceptually with PH012/PH013 but emphasises systemic adaptive capacity rather than condition-specific energy stability labels. (origin: BRAIN)
Related phenomes: PH012 — Energy Stability Under Variable Conditions, PH013 — Energy Stability Under Variable Fuel Conditions
External framework cross-references
RDoC domains
- Arousal and Regulatory Systems — metabolic / physiological regulation
ICF domains
- Body functions — metabolic and energy production functions
Foundational Evidence
Evidence Confidence: Low–Medium
Registry-level score for this phenome's foundational evidence stack — not Biology → Phenome Confidence on individual mechanism pages.
Metabolic-flexibility and ketone-body reviews anchor the construct; ketone intervention human evidence supports substrate biology more than broad metabolic-resilience phenome endpoints.
Registry-level foundational evidence for this phenome. Mechanism pages link to phenome IDs and carry relationship-specific evidence — not duplicated here.
Construct landmark papers
- Goodpaster & Sparks (2017) — Canonical metabolic flexibility construct and measurement framing.
- Smith et al. (2018) — Metabolic flexibility in health and disease — resilience under variable demand.
Biology → phenome landmark papers
- Kyriazis et al. (2022) — Ketone bodies and brain energy metabolism — adaptive substrate biology.
- Packer et al. (1997) — CoQ10 and mitochondrial antioxidant biology supporting metabolic resilience.
Nutrition → biology landmark papers
- Lopez-Ojeda et al. (2023) — Ketogenic and ketone-body dietary contexts modulate brain energy substrate biology.
- Ramezani et al. (2023) — Ketone ester supplementation and metabolic substrate flexibility in humans.
Connected mechanisms
BRS4
- BRS4-FM2-PM4 — ROS Production and Control (modulates · low-medium)
- BRS4-FM2-PM5 — Mitochondrial Protection (Redox Integrity) (supports · low-medium)
- BRS4-FM3-PM6 — Carnitine-Mediated Fat Transport (supports · low-medium)
- BRS4-FM3-PM7 — Ketone Utilisation Capacity (supports · low)
- BRS4-FM3-PM8 — Metabolic Fuel Switching (supports · low-medium)
- BRS4-FM4-PM9 — Mitochondrial Biogenesis (supports · low-medium)