PH013 — Energy Stability Under Variable Fuel Conditions
Capacity to maintain ATP-linked energy supply when available fuel substrates or macronutrient context change.
How well energy supply holds when glucose, fat, ketone, or mixed fuel availability changes.
Therapeutic areas: TA001 ★TA005TA006TA007
Provenance: Core Version 1 registry phenome for ATP-linked supply when macronutrient/fuel context changes. Paired with PH012 under RF001 near-duplicate review — PH013 retains substrate-specific framing. (origin: BRAIN)
Related phenomes: PH012 — Energy Stability Under Variable Conditions, PH007 — Metabolic Resilience
External framework cross-references
RDoC domains
- Arousal and Regulatory Systems — metabolic / substrate regulation
Foundational Evidence
Evidence Confidence: Low–Medium
Registry-level score for this phenome's foundational evidence stack — not Biology → Phenome Confidence on individual mechanism pages.
Ketone and glucose-efficiency human studies support fuel-switching biology; registry stack does not demonstrate dietary fuel-manipulation trials as energy-phenome primary endpoints.
Registry-level foundational evidence for this phenome. Mechanism pages link to phenome IDs and carry relationship-specific evidence — not duplicated here.
Construct landmark papers
- van Oudheusden et al. (2002) — Efficacy of glucose and fuel interventions on cognitive performance — fuel-availability construct.
- Lopez-Ojeda et al. (2023) — Ketone bodies as alternative fuel — variable substrate framing.
Biology → phenome landmark papers
- Ramezani et al. (2023) — Ketone ester effects on substrate utilisation and brain energy biology.
- Kyriazis et al. (2022) — Ketone metabolism and brain energetic adaptation under fuel change.
Nutrition → biology landmark papers
- Lopez-Ojeda et al. (2023) — Dietary ketogenic context modulates ketone-body fuel biology.
- van Oudheusden et al. (2002) — Glucose administration and cognitive fuel-supply intervention evidence.
Connected mechanisms
BRS4
- BRS4-FM3-PM6 — Carnitine-Mediated Fat Transport (modulates · low-medium)
- BRS4-FM3-PM7 — Ketone Utilisation Capacity (modulates · low-medium)