BRS2-FM2-PM6 - Glutathione Synthesis
1. Definition
Synthesis of glutathione from cysteine, glycine, and related cofactors downstream of transsulfuration.
2. Functional Role
↑ antioxidant capacity
3. Target Functional Outcome / Phenome
These mappings are translational relationships, not single-mechanism outcome claims. Phenomes are emergent functional patterns supported by multiple interacting PMs across the BRAIN Framework.
No direct functional outcome relationship currently mapped.
4. Levers
Intervention Profile
Intervention Dominance: Diet-Dominant
4.1 Dietary Levers
4.1.1 Direct Dietary Levers
- Cofactor density ← brazil nuts, seafood
- Cysteine ← eggs, legumes
- Glycine ← eggs, legumes
- Selenium ← brazil nuts, seafood
4.1.2 Cofactors and Supporting Inputs
- selenium
- riboflavin
4.1.3 KCs (Key Constraints)
4.2 Lifestyle Levers
- Consistent daily meal timing may support one-carbon and methyl-donor availability across the day.
- Sleep and stress context may indirectly affect methylation demand; lifestyle factors are secondary to dietary substrate supply for this PM.
5. Mechanistic Basis
Summary
Synthesis of glutathione from cysteine, glycine, and related cofactors downstream of transsulfuration.
Glutathione Synthesis — mechanistic detail
(Glutathione Synthesis)
Synthesis of glutathione from cysteine, glycine, and related cofactors downstream of transsulfuration. Integrates BRS2 with redox resilience
6. BRS Pathways and Connections
6.1 BRS Pathways
- None listed
6.2 Connected BRS Mechanisms
- None listed
6.3 Connected Primary Mechanisms
7. Scoreable Inputs & Modulation Signals
Scoreable Input Categories
| Input Category | Example Inputs | PM relevance |
|---|---|---|
| Functional Property Potentials | methyl_donor_pattern; sulfur_amino_acid_context; choline_rich_food_matrix | May support glutathione synthesis. |
| Realised Functional States | consistent_daily_methyl_donor_coverage | May reflect meal-level pathway support. |
| Preparation Transformations | minimally_processed; whole_food_matrix | May preserve nutrient density for pathway support. |