BRS6(PM3) - Cortisol Rhythm Regulation
Regulation of the diurnal cortisol pattern, especially morning activation and evening downshift.
Biological Role
↑ diurnal cortisol rhythm stability; ↓ evening stress-hormone drift
Dependencies (System Requirements)
KCs
- BRS6(KC1) - Glucose / Energy Substrate Availability
- BRS6(KC2) - Stress-Response Micronutrient & Lipid Sufficiency
Optional BRSX Modifiers
- None listed
Cofactors (Chemical Enablement)
- vitamin C
- magnesium
- B5
- B6
Inputs (Dietary and Environmental)
regular breakfast / meal timing → metabolic timing signal; daylight exposure → morning circadian cue; consistent sleep timing → cortisol rhythm stability; late-night eating / light → antagonistic circadian signal
Outputs / Biological Effects
↑ diurnal cortisol rhythm stability; ↓ evening stress-hormone drift
Functional Mechanism Ownership
- BRS6(FM2)
Intervention Dominance
- Lifestyle-Dominant
Constraints and Failure Modes
[INSERT_FROM_COLUMN_N_OR_SHEET_NOTES_IF_AVAILABLE]
Notes
- Evidence Type (Column H): Human + mechanistic
- Evidence/Notes (Column N): Not diet-only. Diet timing is one entrainment signal among light, sleep, and stress load.
Mechanism Summary Table
| Field | Value |
|---|---|
| PM ID | BRS6(PM3) |
| FM Ownership (Column P) | BRS6(FM2) |
| Dose Target / Requirement (Column J) | Daily consistency of sleep, light, and feeding cues |
| Coverage Timing (Column K) | Daily |
| Response Type (Column L) | Hours–Days |
| Functional Latency (Column M) | Same day–Days |
References
- Missing bibliography entry: [Stenvers et al. (2019) — https://pubmed.ncbi.nlm.nih.gov/31152883/]
- Missing bibliography entry: [Scheer et al. (2009) — https://pubmed.ncbi.nlm.nih.gov/19255424/]
Missing Entities
- None flagged from this row-level pass