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BRS5 — Gut-Brain Axis & Enteric Nervous System

BRS5(KC3) - Barrier-Supportive Nutrient Sufficiency

1. Ambition

Maintain barrier-supportive nutrient sufficiency so epithelial renewal, mucosal immune containment, and selective gut permeability remain stable.

2. Shared Biological Pool

  • Omega-3 fatty acids ← oily fish, algae, eggs
  • Vitamin A precursors and retinol ← eggs, liver, orange vegetables
  • Zinc ← seafood, meat, legumes, seeds
  • Glutamine-supportive amino-acid pool ← fish, eggs, poultry, legumes

3. Biological Importance

Gut-barrier function depends on microbial metabolites and on adequate structural and immune-supportive nutrient context [Mohammad and Thiemermann, 2021; Khailova et al., 2017]. When support is weak, epithelial integrity and selective permeability become harder to maintain, increasing vulnerability to inflammatory spillover and unstable gut-brain signalling.

4. Connected Mechanisms

Functional Mechanisms

Primary Mechanisms

5. Key References