BRS5 - Gut-Brain Axis & Enteric Nervous System
Peripheral neural-immune interface covering gut barrier, microbial signalling, ENS, and vagal pathways.
Peripheral neural-immune interface covering gut barrier, microbial signalling, ENS, and vagal pathways.
Endogenous γ-glutamyl-cysteinyl-glycine tripeptide and GSH/GSSG redox resource pool; nutritionally relevant through precursor supply, synthesis and recycling rather than as a vitamin.
Principal sesame lignan; preliminary cardiometabolic trials, null food-level findings, and incomplete translation to ordinary servings.
Hydrolysable tannins that release ellagic acid. They are the upstream class, not ellagic acid and not urolithin A.
The microbial substrate for urolithin formation. Conversion depends on the community and can stop at intermediates. It is not urolithin A.
Microbial short-chain fatty acid; gut–brain research remains distinct from evidence of clinical benefit.
Key SCFA supporting mitochondrial function, gut barrier integrity, and neuroinflammation reduction
Microbiome-derived metabolite from ellagitannins; supports mitochondrial resilience and mitophagy
Amino acid and the substrate of GAD and of the first step of glutathione assembly. Intracellular roles are not a requirement to eat glutamate.
Amino acid used by enterocytes. Adult trials do not show a general permeability benefit. A postinfectious IBS supplement result stays in that group.
A branched α-L-arabinofuranose polysaccharide and a neutral side chain of pectin. Local evidence is one pea-fibre arabinan, not every arabinan source.
Combined fructo-oligosaccharide and galacto-oligosaccharide identity for records that name both classes together.
A class of plant cell-wall polysaccharides. Apple pectin, citrus pectin, and generic fermentation substrates are separate evidence records.
Starch that escapes small-intestinal digestion. Type 2 mouse feeding, resistant potato starch, and RS2/RS3 cultures are separate exposures.
Longer-chain inulin-type fructan. The mouse mucus result used oligofructose-enriched inulin, which is not inulin alone and not oligofructose alone.
The sugar used as a luminal sensory stimulus in a mouse neuropod–vagal circuit. That experiment is not a reason to eat more glucose.
Essential cuproenzyme cofactor for catecholamine synthesis, iron efflux and redox defence; mapped to BRS1, BRS3, BRS5 and BRS6.
Cofactor in neurotransmission and antioxidant enzymes; dopamine modulation