Ghee

Overview

Ghee is clarified butter providing butyrate, vitamins A/D/E/K2, and heat stability, making it suitable for high-heat cooking. Ghee provides butyrate, vitamins A/D/E/K2, is heat-stable, and low in lactose/casein, making it suitable for high-heat cooking and Ayurvedic dishes.

Recipes

no recipes found

Substances

5 substances in this food

Butyrate

Key SCFA supporting mitochondrial function, gut barrier integrity, and neuroinflammation reduction

Vitamin A (Retinoids; β-Carotene precursor)

Neurodevelopment; immune regulation; antioxidant via carotenoids

Vitamin D

Neurotrophic and immune modulation; calcium homeostasis

Vitamin E (Tocopherols/Tocotrienols)

Lipid-phase antioxidant; protects PUFA (DHA) in membranes

Vitamin K2 (MK forms)

Calcium handling; potential roles in brain health; often co-occurs with fat-soluble vitamins

Preparation Notes

• Heat-stable for high-heat cooking
• Low in lactose/casein (suitable for some sensitivities)
• Part of stable cooking fat strategy
• Supports butyrate intake

Biological Target Matrix

Biological Target	Substance	Contribution Level	Therapeutic Areas	Mechanism of Action
Gut Microbiome	Butyrate	Contextual / minor contributor	ADHD, Anxiety & GAD, Depression & MDD	Byproduct of fibre fermentation; supports intestinal barrier integrity; regulates immune responses; promotes synthesis of key neurotransmitters such as dopamine and serotonin
Gut Microbiome	Vitamin D	Contextual / minor contributor	ADHD, Anxiety & GAD, Depression & MDD	Supports gut barrier integrity; nutrient deficiencies including vitamin D disrupt tight junctions, increasing permeability
Hormonal Response	Vitamin D	Contextual / minor contributor	ADHD, Anxiety & GAD	Modulates neurotrophic factors vital for survival and growth of neurons; supports calcium homeostasis and calcium handling
Hormonal Response	Vitamin K2 (MK forms)	Contextual / minor contributor	ADHD, Anxiety & GAD	Modulates calcium distribution; supports calcium handling and may support neural function; occurs in fermented foods and certain animal products
Inflammation	Butyrate	Contextual / minor contributor	ADHD, Anxiety & GAD, Depression & MDD, Alzheimer's Disease, Bipolar Disorder	Has anti-inflammatory effects, potentially reducing neuroinflammation; deficiencies linked to many neurological disorders including ADHD
Insulin Response	Butyrate	Contextual / minor contributor	ADHD, Anxiety & GAD, Depression & MDD	Improves insulin sensitivity and glucose metabolism; helps stabilize blood glucose and reduce insulin resistance
Mitochondrial Support	Butyrate	Contextual / minor contributor	ADHD, Anxiety & GAD, Depression & MDD, Alzheimer's Disease, Bipolar Disorder	Supports mitochondrial function, enhancing brain energy metabolism; aids in reducing cholesterol and neuroinflammation
Oxidative Stress	Butyrate	Contextual / minor contributor	ADHD, Anxiety & GAD, Depression & MDD, Alzheimer's Disease, Bipolar Disorder	Enhances mitochondrial function during oxidative stress; supports antioxidant activity
Oxidative Stress	Vitamin A (Retinoids; β-Carotene precursor)	Contextual / minor contributor	ADHD, Anxiety & GAD, Depression & MDD, Alzheimer's Disease, Bipolar Disorder	Provitamin A carotenoids (β-carotene) act as antioxidants in neural tissue; contribute to antioxidant network
Oxidative Stress	Vitamin E (Tocopherols/Tocotrienols)	Contextual / minor contributor	ADHD, Anxiety & GAD, Depression & MDD, Alzheimer's Disease, Bipolar Disorder	Lipid-phase antioxidant; protects polyunsaturated fatty acids in membranes from peroxidation; works within antioxidant network with vitamin C, CoQ10, and polyphenols
Stress Response	Vitamin D	Contextual / minor contributor	ADHD, Anxiety & GAD, Depression & MDD	Modulates immune responses to reduce inflammation in the brain; supports stress response through neurotrophic and immune effects

References

• Ghee: Butyrate, vitamins A/D/E/K2, heat-stable, low in lactose/casein - High-heat cooking, Ayurvedic dishes
• Replacing industrial seed oils with more stable options like olive oil, ghee, or avocado oil