BRS2-FM3-PM7 - Phospholipid Methylation
1. Definition
SAMe-dependent methylation of phospholipids affecting membrane composition and receptor function.
2. Target Functional Outcome / Phenome
These mappings are translational relationships, not single-mechanism outcome claims. Phenomes are emergent functional patterns supported by multiple interacting PMs across the BRAIN Framework.
No direct functional outcome relationship currently mapped.
3. Intervention Breakdown
Food-State Dominant
4. Functional Role
↑ membrane methylation; ↑ fluidity
5. Mechanistic Basis
Summary
SAMe-dependent methylation of phospholipids affecting membrane composition and receptor function.
Phospholipid Methylation — mechanistic detail
(Phospholipid Methylation)
SAMe-dependent methylation of phospholipids affecting membrane composition and receptor function. Captures the membrane arm emphasized in the manuscript
6. Connected BRS2 Mechanisms
6.1 Overarching Functional Mechanism
6.2 Connected Primary Mechanisms
7. Connected Mechanisms
- None listed
8. Dietary Levers
8.1 Direct Dietary Levers
- Choline ← eggs, fish roe
- DHA ← oily fish, algal oil
- EPA ← oily fish, algal oil
- EPA/DHA
- Phosphatidylcholine ← eggs, fish roe
- SAME
8.2 Cofactors and Supporting Inputs
- magnesium (indirect — supports SAMe-dependent phospholipid methylation)
8.3 KCs (Key Constraints)
9. Lifestyle Levers
Lifestyle
- Consistent daily meal timing may support one-carbon and methyl-donor availability across the day.
- Sleep and stress context may indirectly affect methylation demand; lifestyle factors are secondary to dietary substrate supply for this PM.
10. Scoreable Inputs & Modulation Signals
Scoreable Input Categories
| Input Category | Example Inputs | PM relevance |
|---|---|---|
| Functional Property Potentials | methyl_donor_pattern; sulfur_amino_acid_context; choline_rich_food_matrix | May support phospholipid methylation. |
| Realised Functional States | consistent_daily_methyl_donor_coverage | May reflect meal-level pathway support. |
| Preparation Transformations | minimally_processed; whole_food_matrix | May preserve nutrient density for pathway support. |