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BRS3 — Inflammation & Oxidative Stress

BRS3(KC1) - Antioxidant Substrate Availability​

1. Definition​

Availability of antioxidant substrates and precursor compounds required to support endogenous antioxidant defence, redox buffering, and oxidative-damage limitation.

2. Constraint Role​

Provides the shared antioxidant substrate pool supporting glutathione synthesis, antioxidant buffering, and protection against oxidative stress. Multiple antioxidant and inflammatory PMs draw upon this pool to maintain redox balance and limit oxidative damage.

3. Shared Biological Pool​

  • Polyphenols
  • Vitamin C
  • Antioxidant phytochemicals
  • Cysteine
  • Glycine
  • Glutamate
  • Sulfur amino acids

4. Biological Importance​

This pool combines direct dietary antioxidant compounds with glutathione-building amino-acid substrates that support endogenous defence systems. Together they contribute to redox buffering, antioxidant recycling, and glutathione-dependent protection. Insufficient availability across either component may increase vulnerability to oxidative damage and reduce resilience across multiple inflammatory and antioxidant mechanisms.

5. Connected Mechanisms​

Functional Mechanisms​

Primary Mechanisms​

6. References​

  1. Packer et al. (1997)
  2. Zelicha et al. (2022)
  3. Houghton et al. (2016)