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BRS3 — Inflammation & Oxidative Stress

BRS3(KC3) - Essential Fatty Acid Balance​

1. Definition​

Availability and balance of omega-3 and omega-6 fatty acids required for inflammatory signalling, membrane composition, and inflammation-resolution pathways.

2. Constraint Role​

Provides the shared structural and signalling lipid pool required for inflammatory mediator production, membrane function, and inflammation-resolution pathways. Supports multiple inflammatory PMs through effects on membrane composition and lipid-derived signalling molecules.

3. Shared Biological Pool​

  • EPA
  • DHA
  • Arachidonic acid
  • Omega-3 fatty acids
  • Omega-6 fatty acids

4. Biological Importance​

Essential fatty acids act as structural membrane components and as precursors for signalling molecules involved in inflammatory activation and resolution. Imbalances in fatty-acid availability may alter inflammatory tone and affect the efficiency of resolution pathways.

5. Connected Mechanisms​

Functional Mechanisms​

Primary Mechanisms​

6. References​

  1. Serhan and Petasis (2011)
  2. Ferguson et al. (2014)
  3. McNamara and Carlson (2006)